{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T17:37:47Z","timestamp":1785173867204,"version":"3.55.0"},"reference-count":134,"publisher":"American Society for Clinical Investigation","issue":"18","license":[{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"vor","delay-in-days":63,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000291","name":"Kidney Research UK","doi-asserted-by":"crossref","award":["IN_012_20190306"],"award-info":[{"award-number":["IN_012_20190306"]}],"id":[{"id":"10.13039\/501100000291","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000833","name":"Rosetrees Trust","doi-asserted-by":"crossref","award":["PhD2020\\100012"],"award-info":[{"award-number":["PhD2020\\100012"]}],"id":[{"id":"10.13039\/501100000833","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000618","name":"Foulkes Foundation","doi-asserted-by":"crossref","award":["Fellowship"],"award-info":[{"award-number":["Fellowship"]}],"id":[{"id":"10.13039\/501100000618","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["220895\/Z\/20\/Z"],"award-info":[{"award-number":["220895\/Z\/20\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Institute for Health Research (NIHR) Biomedical Research Centre at Great Ormond Street Hospital","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"Medical Research Council","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["314710\/Z\/24\/Z"],"award-info":[{"award-number":["314710\/Z\/24\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Medical Research Council","award":["APP14742"],"award-info":[{"award-number":["APP14742"]}]},{"name":"Medical Research Council (MRC)-National Institute for Health and Care Research (NIHR) Rare Disease Research Platform","award":["MR\/Y008340\/1"],"award-info":[{"award-number":["MR\/Y008340\/1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,16]]},"abstract":"<jats:p>\n                    Lymphatic vessels maintain tissue fluid homeostasis and modulate inflammation, yet their spatial organization and molecular identity in the healthy human kidney, and how these change during chronic transplant rejection, remain poorly defined. Here, we show that lymphatic capillaries initiate adjacent to cortical kidney tubules and lack smooth muscle coverage. These vessels exhibit an organ-specific molecular signature, enriched for\n                    <jats:italic>CCL14<\/jats:italic>\n                    ,\n                    <jats:italic>DNASE1L3<\/jats:italic>\n                    , and\n                    <jats:italic>MDK<\/jats:italic>\n                    , with limited expression of canonical immune-trafficking markers found in other organ lymphatics, such as\n                    <jats:italic>LYVE1<\/jats:italic>\n                    and\n                    <jats:italic>CXCL8<\/jats:italic>\n                    . In allografts with chronic mixed rejection, lymphatics become disorganized and infiltrate the medulla, with their endothelial junctions remodeling from a button-like to a continuous, zipper-like, architecture. Lymphatics in rejecting kidneys localize around and interconnect tertiary lymphoid structures at different maturation stages, with altered intralymphatic and perilymphatic CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell distribution. The infiltrating T cells express IFN-\u03b3, which upregulates coinhibitory ligands in lymphatic endothelial cells, including PVR and LGALS9. Simultaneously, lymphatics acquire HLA class II expression and exhibit C4d deposition, consistent with alloantibody binding and complement activation. Together, these findings define the spatial and molecular features of human kidney lymphatics, revealing tolerogenic reprogramming accompanied by structural perturbations during chronic transplant rejection.\n                  <\/jats:p>","DOI":"10.1172\/jci168962","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T16:00:58Z","timestamp":1752595258000},"source":"Crossref","is-referenced-by-count":11,"title":["Organ-specific features of human kidney lymphatics are disrupted in chronic transplant rejection"],"prefix":"10.1172","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8235-0394","authenticated-orcid":true,"given":"Daniyal J.","family":"Jafree","sequence":"first","affiliation":[{"name":"Developmental Biology & Cancer Research & Teaching Department, University College London (UCL) Great Ormond Street Institute of Child Health,"},{"name":"UCL Centre for Kidney & Bladder Health, and"},{"name":"UCL MB\/PhD Programme, UCL, London, United Kingdom."},{"name":"Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin J.","family":"Stewart","sequence":"additional","affiliation":[{"name":"Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom."},{"name":"Molecular Immunity Unit, University of Cambridge, Cambridge, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L.","family":"Price","sequence":"additional","affiliation":[{"name":"Developmental Biology & Cancer Research & Teaching Department, University College London (UCL) Great Ormond Street Institute of Child Health,"},{"name":"UCL Centre for Kidney & Bladder Health, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1636-3968","authenticated-orcid":true,"given":"Maria","family":"Kolatsi-Joannou","sequence":"additional","affiliation":[{"name":"Developmental Biology & Cancer Research & Teaching Department, University College London (UCL) Great Ormond Street Institute of Child Health,"},{"name":"UCL Centre for Kidney & Bladder Health, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Laroche","sequence":"additional","affiliation":[{"name":"Developmental Biology & Cancer Research & Teaching Department, University College London (UCL) Great Ormond Street Institute of Child Health,"},{"name":"UCL Centre for Kidney & Bladder Health, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barian","family":"Mohidin","sequence":"additional","affiliation":[{"name":"Developmental Biology & Cancer Research & Teaching Department, University College London (UCL) Great Ormond Street Institute of Child Health,"},{"name":"UCL Centre for Kidney & Bladder Health, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Davis","sequence":"additional","affiliation":[{"name":"Central Laser Facility, Science and Technologies Facilities Council, UK Research and Innovation, Didcot, Oxfordshire, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Mathematical Sciences Research Centre, Queen\u2019s University Belfast, Belfast, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren G","family":"Russell","sequence":"additional","affiliation":[{"name":"Developmental Biology & Cancer Research & Teaching Department, University College London (UCL) Great Ormond Street Institute of Child Health,"},{"name":"UCL Centre for Kidney & Bladder Health, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda Marinas","family":"del Rey","sequence":"additional","affiliation":[{"name":"UCL Centre for Kidney & Bladder Health, and"},{"name":"Research Department of Surgical Biotechnology, Division of Surgery and Interventional Science,"},{"name":"UCL Institute of Immunity and Transplantation, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"UCL Institute of Immunity and Transplantation, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J","family":"Mason","sequence":"additional","affiliation":[{"name":"Developmental Biology & Cancer Research & Teaching Department, University College London (UCL) Great Ormond Street Institute of Child Health,"},{"name":"UCL Centre for Kidney & Bladder Health, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Il","family":"Lee","sequence":"additional","affiliation":[{"name":"UK Dementia Research Institute at UCL, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Heptinstall","sequence":"additional","affiliation":[{"name":"UCL Centre for Kidney & Bladder Health, and"},{"name":"UCL Department of Pathology, Royal Free Hospital, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayshwarya","family":"Subramanian","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, College of Arts and Science, Cornell University, Ithaca, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gideon","family":"Pomeranz","sequence":"additional","affiliation":[{"name":"Developmental Biology & Cancer Research & Teaching Department, University College London (UCL) Great Ormond Street Institute of Child Health,"},{"name":"UCL Centre for Kidney & Bladder Health, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1431-7047","authenticated-orcid":true,"given":"Dale","family":"Moulding","sequence":"additional","affiliation":[{"name":"Developmental Biology & Cancer Research & Teaching Department, University College London (UCL) Great Ormond Street Institute of Child Health,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Wilson","sequence":"additional","affiliation":[{"name":"Developmental Biology & Cancer Research & Teaching Department, University College London (UCL) Great Ormond Street Institute of Child Health,"},{"name":"UCL Centre for Kidney & Bladder Health, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahmina","family":"Wickenden","sequence":"additional","affiliation":[{"name":"Developmental Biology & Cancer Research & Teaching Department, University College London (UCL) Great Ormond Street Institute of Child Health,"},{"name":"UCL Centre for Kidney & Bladder Health, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saif N.","family":"Malik","sequence":"additional","affiliation":[{"name":"Developmental Biology & Cancer Research & Teaching Department, University College London (UCL) Great Ormond Street Institute of Child Health,"},{"name":"UCL Centre for Kidney & Bladder Health, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Holroyd","sequence":"additional","affiliation":[{"name":"UCL Centre for Advanced Biomedical Imaging, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire L.","family":"Walsh","sequence":"additional","affiliation":[{"name":"UCL Centre for Advanced Biomedical Imaging, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9785-4528","authenticated-orcid":true,"given":"Jennifer C.","family":"Chandler","sequence":"additional","affiliation":[{"name":"Developmental Biology & Cancer Research & Teaching Department, University College London (UCL) Great Ormond Street Institute of Child Health,"},{"name":"UCL Centre for Kidney & Bladder Health, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin X.","family":"Cao","sequence":"additional","affiliation":[{"name":"Developmental Biology & Cancer Research & Teaching Department, University College London (UCL) Great Ormond Street Institute of Child Health,"},{"name":"UCL Centre for Kidney & Bladder Health, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.D.","family":"Winyard","sequence":"additional","affiliation":[{"name":"Developmental Biology & Cancer Research & Teaching Department, University College London (UCL) Great Ormond Street Institute of Child Health,"},{"name":"UCL Centre for Kidney & Bladder Health, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5541-1358","authenticated-orcid":true,"given":"Adrian S.","family":"Woolf","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc Aurel","family":"Busche","sequence":"additional","affiliation":[{"name":"UK Dementia Research Institute at UCL, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Walker-Samuel","sequence":"additional","affiliation":[{"name":"UCL Centre for Advanced Biomedical Imaging, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy S.K.","family":"Walker","sequence":"additional","affiliation":[{"name":"UCL Institute of Immunity and Transplantation, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8973-4021","authenticated-orcid":true,"given":"Tessa","family":"Crompton","sequence":"additional","affiliation":[{"name":"Infection, Immunity and Inflammation Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, UCL, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Scambler","sequence":"additional","affiliation":[{"name":"Developmental Biology & Cancer Research & Teaching Department, University College London (UCL) Great Ormond Street Institute of Child Health,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5399-9546","authenticated-orcid":true,"given":"Reza","family":"Motallebzadeh","sequence":"additional","affiliation":[{"name":"UCL Centre for Kidney & Bladder Health, and"},{"name":"Research Department of Surgical Biotechnology, Division of Surgery and Interventional Science,"},{"name":"UCL Institute of Immunity and Transplantation, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3340-9828","authenticated-orcid":true,"given":"Menna R.","family":"Clatworthy","sequence":"additional","affiliation":[{"name":"Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom."},{"name":"Molecular Immunity Unit, University of Cambridge, Cambridge, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6580-3435","authenticated-orcid":true,"given":"David A.","family":"Long","sequence":"additional","affiliation":[{"name":"Developmental Biology & Cancer Research & Teaching Department, University College London (UCL) Great Ormond Street Institute of Child Health,"},{"name":"UCL Centre for Kidney & Bladder Health, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2025,7,15]]},"reference":[{"issue":"2","key":"B1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.cell.2020.06.039","article-title":"The lymphatic vasculature in the 21st century: novel functional roles in homeostasis and disease","volume":"182","author":"Oliver","year":"2020","journal-title":"Cell"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aax4063"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2021.07.003"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23546-6"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.020143"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1172\/JCI97192"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.312617"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1912-x"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03489-0"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0227-9"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2019121320"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0000000000000120"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040-4603.2023.tb00276.x"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-021-00438-y"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-021-00411-9"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.48183"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2014530"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2018111101"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2408835"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15898"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15806"},{"issue":"11","key":"B22","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1097\/TP.0b013e3181c1afa7","article-title":"Restorative and rejection-associated lymphangiogenesis after renal transplantation: friend or foe?","volume":"88","author":"Vass","year":"2009","journal-title":"Transplantation"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2012.01482.x"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000266689.93615.cd"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12005"},{"issue":"3","key":"B26","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1097\/01.ASN.0000113316.52371.2E","article-title":"Lymphatic neoangiogenesis in human kidney transplants is associated with immunologically active lymphocytic infiltrates","volume":"15","author":"Kerjaschki","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-016-1338-9"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01638.x"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2019.07.027"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.2.706"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.796260"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.060554"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.661"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2021.12.029"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajt.2023.10.016"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052891"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880543"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2021010061"},{"issue":"6","key":"B39","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0092-8674(00)81511-1","article-title":"Prox1 function is required for the development of the murine lymphatic system","volume":"98","author":"Wigle","year":"1999","journal-title":"Cell"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/21.7.1505"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.144.4.789"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001490303"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00251"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.13568"},{"issue":"9","key":"B45","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1111\/nep.13444","article-title":"Renal expression of trefoil factor 3 mRNA in association with tubulointerstitial fibrosis in IgA nephropathy","volume":"23","author":"Tanaka","year":"2018","journal-title":"Nephrology (Carlton)"},{"issue":"22","key":"B46","doi-asserted-by":"crossref","first-page":"3657","DOI":"10.2174\/0929867325666181008154622","article-title":"Role of fatty acid binding protein 4 (FABP4) in kidney disease","volume":"27","author":"Shi","year":"2020","journal-title":"Curr Med Chem"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0127429"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2017090962"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-010-1098-x"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.104097"},{"issue":"4","key":"B51","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1093\/cvr\/cvw175","article-title":"Heterogeneity in the lymphatic vascular system and its origin","volume":"111","author":"Ulvmar","year":"2016","journal-title":"Cardiovasc Res"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1172\/JCI125044"},{"issue":"19","key":"B53","first-page":"3590","article-title":"Smooth muscle cell recruitment to lymphatic vessels requires PDGFB and impacts vessel size but not identity","volume":"144","author":"Wang","year":"2017","journal-title":"Development"},{"key":"B54","doi-asserted-by":"crossref","unstructured":"Subramanian A, et al. Obesity-instructed TREM2 macrophages identified by comparative analysis of diabetic mouse and human kidney at single cell resolution [preprint]. https:\/\/doi.org\/10.1101\/2021.05.30.446342 Posted on bioRxiv May 30, 2021","DOI":"10.1101\/2021.05.30.446342"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.04.019"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20171868"},{"issue":"3","key":"B57","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.devcel.2018.03.021","article-title":"Emerging concepts in organ-specific lymphatic vessels and metabolic regulation of lymphatic development","volume":"45","author":"Wong","year":"2018","journal-title":"Dev Cell"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1126\/science.aba6500"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06252-9"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06311-1"},{"issue":"7838","key":"B61","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/s41586-020-2797-4","article-title":"Cells of the adult human heart","volume":"588","author":"Litvi\u0148ukov\u00e1","year":"2020","journal-title":"Nature"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02327-2"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03852-1"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2009.06.017"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1172\/JCI180984"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2022.155891"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-186973"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.02.019"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20211830"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2023.08.014"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2004.04.002"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15699"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.03106"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.0000000000000202"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.02.023"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.87680"},{"issue":"1","key":"B77","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1681\/ASN.2021050715","article-title":"Advanced tertiary lymphoid tissues in protocol biopsies are associated with progressive graft dysfunction in kidney transplant recipients","volume":"33","author":"Lee","year":"2022","journal-title":"J Am Soc Nephrol"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2021040575"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2024.03.028"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00491"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfab212"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-01747-8"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.41239"},{"issue":"1","key":"B84","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-29701-x","article-title":"Loss of vascular endothelial notch signaling promotes spontaneous formation of tertiary lymphoid structures","volume":"13","author":"Fleig","year":"2022","journal-title":"Nat Commun"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-020-0292-x"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.05.001"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.72.3.486"},{"issue":"5","key":"B88","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1161\/ATVBAHA.111.224162","article-title":"CD155 on human vascular endothelial cells attenuates the acquisition of effector functions in CD8 T cells","volume":"31","author":"Escalante","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1002\/2211-5463.12854"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.135.6.3750"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1038\/nm1340"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000061778.08085.9F"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.059002488.x"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014090856"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2017.77"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.312765"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000002349"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1042\/CS20220547"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpz139"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1038\/nature21028"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0844"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-0179com"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1714446115"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1172\/JCI155478"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03376-x"},{"key":"B106","doi-asserted-by":"crossref","unstructured":"Funk EM, et al. Nanobody immunolabelling and three-dimensional imaging reveals spatially restricted LYVE1 expression by kidney lymphatic vessels in mice [preprint]. https:\/\/doi.org\/10.1101\/2024.08.09.607309 Posted on bioRxiv August 9, 2024","DOI":"10.1101\/2024.08.09.607309"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20201138"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.177003"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1038\/ng.975"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.0000000000000325"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1038\/s44161-023-00257-3"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06899-4"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20220741"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00066"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800271"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20180654"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0180206"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2006.08.003"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-20-0784"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-023-01443-y"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01158-6"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.10.003"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1172\/JCI71611"},{"issue":"11","key":"B124","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1016\/j.ajpath.2020.07.015","article-title":"Kidney tertiary lymphoid structures in lupus nephritis develop into large interconnected networks and resemble lymph nodes in gene signature","volume":"190","author":"Dorraji","year":"2020","journal-title":"Am J Pathol"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.02.001"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.1.221"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.06.016"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.01.030"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0554-0"},{"issue":"6","key":"B130","first-page":"462","article-title":"Building skeleton models via 3-D medial surface axis thinning algorithms","volume":"56","author":"Lee","year":"1994","journal-title":"CVGIP: Graphical Models and Image Processing"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.2006.01706.x"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-018-0229-2"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0619-0"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-023-01938-4"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/168962\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T17:57:13Z","timestamp":1779213433000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/168962"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,15]]},"references-count":134,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2025,9,16]]},"published-print":{"date-parts":[[2025,9,16]]}},"alternative-id":["10.1172\/JCI168962"],"URL":"https:\/\/doi.org\/10.1172\/jci168962","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,15]]},"article-number":"e168962"}}