{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T23:35:30Z","timestamp":1781566530803,"version":"3.54.5"},"reference-count":13,"publisher":"American Society for Clinical Investigation","issue":"10","license":[{"start":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T00:00:00Z","timestamp":1684108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,15]]},"DOI":"10.1172\/jci170226","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T12:46:19Z","timestamp":1684154779000},"source":"Crossref","is-referenced-by-count":4,"title":["Paving a way to treat spastic paraplegia 50"],"prefix":"10.1172","volume":"133","author":[{"given":"Jonathan R.","family":"Brent","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Xiang","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2023,5,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.690899"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30235-2"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.06.004"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36514"},{"key":"B5"},{"issue":"10","key":"B6","first-page":"2929","article-title":"Defining the clinical, molecular and imaging spectrum of adaptor protein complex 4-associated hereditary spastic paraplegia","volume":"143","author":"Ebrahimi-Fakhari","year":"2020","journal-title":"Brain"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.04.019"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1042\/BST20190664"},{"key":"B9","article-title":"Intrathecal AAV9\/AP4M1 gene therapy for hereditary spastic paraplegia 50 shows safety and efficacy in preclinical studies","volume":"164575","author":"Chen","year":"2023","journal-title":"J Clin Invest"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm251"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(99)00018-2"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-003-1393-9"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2016.013"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/170226\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T17:48:29Z","timestamp":1691084909000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/170226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,15]]},"references-count":13,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,5,15]]},"published-print":{"date-parts":[[2023,5,15]]}},"alternative-id":["10.1172\/JCI170226"],"URL":"https:\/\/doi.org\/10.1172\/jci170226","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,15]]},"article-number":"e170226"}}