{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:20:14Z","timestamp":1790886014255,"version":"4.1.0"},"reference-count":46,"publisher":"American Society for Clinical Investigation","issue":"13","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":48,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01CA200653,F30CA232397,CA190429,R01CA236890,P30CA013148,AG050886"],"award-info":[{"award-number":["R01CA200653,F30CA232397,CA190429,R01CA236890,P30CA013148,AG050886"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"crossref","award":["I01BX002930"],"award-info":[{"award-number":["I01BX002930"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,1]]},"abstract":"<jats:p>\n                    Tumor cells are known to undergo considerable metabolic reprogramming to meet their unique demands and drive tumor growth. At the same time, this reprogramming may come at a cost with resultant metabolic vulnerabilities. The small molecule l-2-hydroxyglutarate (l-2HG) is elevated in the most common histology of renal cancer. Similarly to other oncometabolites, l-2HG has the potential to profoundly impact gene expression. Here, we demonstrate that l-2HG remodels amino acid metabolism in renal cancer cells through combined effects on histone methylation and RNA\n                    <jats:italic>N<\/jats:italic>\n                    <jats:sup>6<\/jats:sup>\n                    -methyladenosine. The combined effects of l-2HG result in a metabolic liability that renders tumors cells reliant on exogenous serine to support proliferation, redox homeostasis, and tumor growth. In concert with these data, high\u2013l-2HG kidney cancers demonstrate reduced expression of multiple serine biosynthetic enzymes. Collectively, our data indicate that high\u2013l-2HG renal tumors could be specifically targeted by strategies that limit serine availability to tumors.\n                  <\/jats:p>","DOI":"10.1172\/jci171294","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T12:00:59Z","timestamp":1715688059000},"source":"Crossref","is-referenced-by-count":12,"title":["l-2-Hydroxyglutarate remodeling of the epigenome and epitranscriptome creates a metabolic vulnerability in kidney cancer models"],"prefix":"10.1172","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0621-9989","authenticated-orcid":true,"given":"Anirban","family":"Kundu","sequence":"first","affiliation":[{"name":"Department of Urology, University of Alabama at Birmingham, Birmingham, Alabama, USA."},{"name":"Department of Urology, University of Arizona, Tuscon, Arizona, 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