{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T03:01:20Z","timestamp":1792206080643,"version":"4.4.0"},"reference-count":164,"publisher":"American Society for Clinical Investigation","issue":"19","license":[{"start":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T00:00:00Z","timestamp":1696204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,2]]},"DOI":"10.1172\/jci171955","type":"journal-article","created":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T14:00:52Z","timestamp":1696168852000},"source":"Crossref","is-referenced-by-count":52,"title":["Mechanosensing Piezo channels in gastrointestinal disorders"],"prefix":"10.1172","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2404-8186","authenticated-orcid":false,"given":"Sandip M.","family":"Swain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5498-4151","authenticated-orcid":false,"given":"Rodger A.","family":"Liddle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2023,10,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.08.049"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.08.032"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2009.02.011"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.7b00305"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021317-121245"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s12551-021-00827-4"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.904203"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.09.026"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2597"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00481.2020"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-014-1635-7"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ctm.2016.11.003"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2006.00880.x"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-63049-w"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00051.2015"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-019-02088-8"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00401.2016"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2018.00010"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/nature14329"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201700164"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.11.020"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1320768111"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/ncpgasthep0055"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00412.2010"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22193"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04194-9"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00502.2005"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00339.2004"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)91022-A"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2011.07.010"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181a77bb4"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8608898"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1172\/JCI134111"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.158288"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-51518-w"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31103-y"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1126\/science.1193270"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1172\/JCI87343"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA120.015059"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.10.033"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-021-00561-y"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-020-00522-z"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1505-8"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1038\/nature25743"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.92"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aat9897"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aat9892"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.31001"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4520"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.33149"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09055-7"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9793010"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.7b00177"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.106275"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2001611118"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.152330"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00214.2019"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.07370"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1485-8"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1038\/nature21407"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1409233111"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/nature13701"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1817070115"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2018-0197OC"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00103.2018"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau6324"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.086090"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1409802111"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23722"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1113\/JP272718"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-021-00168-8"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1414298111"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1002\/path.5553"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abb5168"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.01.056"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1038\/nature13251"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1038\/nature20793"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12364"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1080\/19336950.2022.2099381"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-72886-8"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2021.02.026"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/403295"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.07369"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.261784"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.24.13126"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1021\/bi200770q"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0303329101"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1038\/nature01807"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199506013322206"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(82)90008-3"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k2126"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65490-9"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.12.036"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30082"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.05.012"},{"issue":"5","key":"B96","first-page":"408","article-title":"Chronic pancreatitis: evolution of the disease","volume":"38","author":"Kl\u00f6ppel","year":"1991","journal-title":"Hepatogastroenterology"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-017-4602-2"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v10.i22.7665"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.20524\/aog.2021.0661"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e318287cd3d"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.09.068"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021014614"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12979"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2007.01019.x"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00237.2016"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-018-2926-7"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1172\/JCI141775"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1990.sp018176"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2021.10.005"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15596"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1804938115"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1038\/nature25744"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1038\/nature10999"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2022.11.015"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602812"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1038\/nature13980"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04860-5"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2019.00178"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.08.017"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.63049"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2021.04.028"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31816b444d"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2023.04.025"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00087.2011"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.05.034"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705762"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00762.x"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1136\/gut.44.5.682"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002356"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.10.026"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2016.07.058"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1136\/gut.14.2.125"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2657-04.2004"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0703-05.2005"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1806-12.2013"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.149724"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-014-3044-3"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2020.11.002"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.1c00505"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.4744"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201902067"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-020-00150-z"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-020-03179-w"},{"issue":"3","key":"B144","first-page":"680","article-title":"HIF-1\u03b1 in colorectal carcinoma: review of the literature","volume":"20","author":"Ioannou","year":"2015","journal-title":"J BUON"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2017.167"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-2063-6"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1002\/mc.22831"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-022-02574-2"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20181679"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28010213"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108609"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.79957"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.818314"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22083805"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2020.102015"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22168470"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izac152"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.208.Supp.113.16"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.1035386"},{"issue":"6","key":"B160","first-page":"591","article-title":"Stress and the gut: pathophysiology, clinical consequences, diagnostic approach and treatment options","volume":"62","author":"Konturek","year":"2011","journal-title":"J Physiol Pharmacol"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01823"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2020.100124"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00500.2004"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119254"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/171955\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T14:01:53Z","timestamp":1696168913000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/171955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,2]]},"references-count":164,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2023,10,2]]},"published-print":{"date-parts":[[2023,10,2]]}},"alternative-id":["10.1172\/JCI171955"],"URL":"https:\/\/doi.org\/10.1172\/jci171955","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,2]]},"article-number":"e171955"}}