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The TGF-\u03b2 superfamily has been implicated in BPD pathogenesis, however, what cell lineage it impacts remains unclear. We show that\n                    <jats:italic>TGFbr2<\/jats:italic>\n                    is critical for alveolar epithelial (AT1) cell fate maintenance and function. Loss of\n                    <jats:italic>TGFbr2<\/jats:italic>\n                    in AT1 cells during late lung development leads to AT1-AT2 cell reprogramming and altered pulmonary architecture, which persists into adulthood. Restriction of fetal lung stretch and associated AT1 cell spreading through a model of oligohydramnios enhances AT1-AT2 reprogramming. Transcriptomic and proteomic analyses reveal the necessity of\n                    <jats:italic>TGFbr2<\/jats:italic>\n                    expression in AT1 cells for extracellular matrix production. Moreover, TGF-\u03b2 signaling regulates integrin transcription to alter AT1 cell morphology, which further impacts ECM expression through changes in mechanotransduction. These data reveal the cell intrinsic necessity of TGF-\u03b2 signaling in maintaining AT1 cell fate and reveal this cell lineage as a major orchestrator of the alveolar matrisome.\n                  <\/jats:p>","DOI":"10.1172\/jci172095","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T14:00:34Z","timestamp":1710424834000},"source":"Crossref","is-referenced-by-count":29,"title":["TGF-\u03b2 controls alveolar type 1 epithelial cell plasticity and alveolar matrisome gene transcription in mice"],"prefix":"10.1172","volume":"134","author":[{"given":"Danielle A.","family":"Callaway","sequence":"first","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA."},{"name":"Penn-CHOP Lung Biology Institute,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian J.","family":"Penkala","sequence":"additional","affiliation":[{"name":"Penn-CHOP Lung Biology 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