{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:20:32Z","timestamp":1790680832754,"version":"4.1.0"},"reference-count":82,"publisher":"American Society for Clinical Investigation","issue":"24","license":[{"start":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T00:00:00Z","timestamp":1702598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,15]]},"DOI":"10.1172\/jci173116","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T12:00:50Z","timestamp":1697544050000},"source":"Crossref","is-referenced-by-count":19,"title":["A gain-of-function p53 mutant synergizes with oncogenic NRAS to promote acute myeloid leukemia in mice"],"prefix":"10.1172","volume":"133","author":[{"given":"Adhithi","family":"Rajagopalan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubin","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meher B.","family":"Gayatri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik A.","family":"Ranheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor","family":"Klungness","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1430-3128","authenticated-orcid":false,"given":"Daniel R.","family":"Matson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon Hee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7258-2888","authenticated-orcid":false,"given":"Mabel Minji","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalyan V.G.","family":"Nadiminti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5320-3280","authenticated-orcid":false,"given":"Vu L.","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Padron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1151-5654","authenticated-orcid":false,"given":"Emery H.","family":"Bresnick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1194-0666","authenticated-orcid":false,"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2023,12,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1406184"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-11-610543"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2017008227"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.99.301"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2864-x"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.2297"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404009"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.124"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23186-w"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021012519"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.08.028"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-375758"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1516192"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-06-719237"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.10320"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2405078"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2014.01.021"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1126\/science.aax3649"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13542-2"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-18-1391"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.171"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2355"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.40"},{"issue":"3","key":"B24","first-page":"1326","article-title":"Dnmt3a haploinsufficiency cooperates with oncogenic Kras to promote an early-onset T-cell acute lymphoblastic leukemia","volume":"9","author":"Chang","year":"2017","journal-title":"Am J Transl Res"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-12-475863"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-04-281527"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-04-280750"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2015.05.003"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/nature12830"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-12-326058"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0010028"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/nature04980"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09234-6"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1013"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.11.019"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401850"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2017.02.025"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.08.090"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1500503"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20191526"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021006182"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-020-0820-2"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1172\/JCI162685"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.106297"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2021.02.008"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.12.012"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2005.09.035"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S182721"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2000039"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3390\/cells7090115"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-4626"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-12-261032"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2018.11.007"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404444"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020002804"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.623952"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021004962"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-01-134262"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0248-0"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-13-0096"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1172\/JCI74182"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.89"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.33.20009"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.645719"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20201169"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021004311"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041419"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.04.008"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-119636"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001893"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103253"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021011758"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.11.5629"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M703856200"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.12.018"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1432147100"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01033-06"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1400065111"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-19-0106"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13164088"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.11.004"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/173116\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T14:04:44Z","timestamp":1702562684000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/173116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,15]]},"references-count":82,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2023,12,15]]},"published-print":{"date-parts":[[2023,12,15]]}},"alternative-id":["10.1172\/JCI173116"],"URL":"https:\/\/doi.org\/10.1172\/jci173116","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,15]]},"article-number":"e173116"}}