{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:12:55Z","timestamp":1792429975164,"version":"4.5.0"},"reference-count":55,"publisher":"American Society for Clinical Investigation","issue":"3","license":[{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,3]]},"abstract":"<jats:p>\n                    Preclinical and clinical observations indicate that the probiotic\n                    <jats:italic>Lactobacillus rhamnosus<\/jats:italic>\n                    GG (LGG) can modulate colonic inflammation. However, the underlying mechanisms have not been explored in depth. Here, we demonstrate that oral administration of live LGG alleviated inflammatory colitis by increasing IL-10 expression in intestinal Ly6C\n                    <jats:sup>+<\/jats:sup>\n                    monocytes. Mechanistically, LGG induced IL-10 production via the stimulator of IFN genes (STING)\/TBK1\/NF-\u03baB (RELA) signaling pathway in intestinal Ly6C\n                    <jats:sup>+<\/jats:sup>\n                    monocytes, enhancing their immune-suppressive function. Elevated IL-10 subsequently activated IL-10 signaling in Ly6C\n                    <jats:sup>+<\/jats:sup>\n                    monocytes, resulting in an IL-10\u2013based autocrine regulatory loop and inhibition of proinflammatory cytokine production. Furthermore, LGG shifted the gut microbial community and its metabolic functions, leading to intestinal immune responses against colitis. Fecal microbiota transplantation from LGG-colonized mice alleviated immune checkpoint blockade\u2013associated colitis. Our findings highlight the importance of STING signaling in IL-10\u2013dependent antiinflammatory immunity and establish an empirical basis for developing oral administration of live LGG as an efficient and safe therapeutic strategy against inflammatory colitis.\n                  <\/jats:p>","DOI":"10.1172\/jci174910","type":"journal-article","created":{"date-parts":[[2025,2,2]],"date-time":"2025-02-02T14:00:45Z","timestamp":1738504845000},"source":"Crossref","is-referenced-by-count":50,"title":["Lactobacillus rhamnosus GG induces STING-dependent IL-10 in intestinal monocytes and alleviates inflammatory colitis in mice"],"prefix":"10.1172","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5277-5142","authenticated-orcid":true,"given":"Wei","family":"Si","sequence":"first","affiliation":[{"name":"State Key Laboratory of Animal Nutrition, Institute of Animal Sciences of Chinese Academy of Agricultural Sciences, Beijing, 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