{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:25:07Z","timestamp":1791361507482,"version":"4.3.1"},"reference-count":46,"publisher":"American Society for Clinical Investigation","issue":"1","license":[{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01HL130253,R01HL157281,P50HD087351"],"award-info":[{"award-number":["R01HL130253,R01HL157281,P50HD087351"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001674","name":"Fondation Leducq","doi-asserted-by":"crossref","award":["Transatlantic Network of Excellence"],"award-info":[{"award-number":["Transatlantic Network of Excellence"]}],"id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"crossref","award":["Big Beat Challenge award to CureHeart"],"award-info":[{"award-number":["Big Beat Challenge award to CureHeart"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["DFG,LE 5009\/1-1"],"award-info":[{"award-number":["DFG,LE 5009\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"crossref","award":["AHA,23POST1026194"],"award-info":[{"award-number":["AHA,23POST1026194"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,2]]},"DOI":"10.1172\/jci175164","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T16:00:29Z","timestamp":1697731229000},"source":"Crossref","is-referenced-by-count":48,"title":["CRISPR-Cas9 base editing of pathogenic CaMKII\u03b4 improves cardiac function in a humanized mouse model"],"prefix":"10.1172","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4525-797X","authenticated-orcid":false,"given":"Simon","family":"Lebek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1173-7003","authenticated-orcid":false,"given":"Xurde M.","family":"Caravia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6738-0130","authenticated-orcid":false,"given":"Leon G.","family":"Straub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damir","family":"Alzhanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4114-8349","authenticated-orcid":false,"given":"Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"McAnally","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5815-4457","authenticated-orcid":false,"given":"Lin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0680-3392","authenticated-orcid":false,"given":"Philipp E.","family":"Scherer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0257-1889","authenticated-orcid":false,"given":"Ning","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7568-410X","authenticated-orcid":false,"given":"Rhonda","family":"Bassel-Duby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric N.","family":"Olson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2024,1,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000950"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.315755"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1172\/JCI65268"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00035"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2014.00021"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.163"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.943431"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.13488"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0813013106"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1126\/science.ade1105"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.276915"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2018.03.020"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.319718"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-018-0688-8"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12020315"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.003313"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.02.048"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.122.320496"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-020-0453-z"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/nature24644"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1126\/science.aba8853"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/nature17946"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.4172"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abg4910"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-02176-5"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2018.015"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2009.182"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.08.028"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.ade1633"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.2741\/3257"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1126\/science.1260419"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-02190-7"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-020-0669-6"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.12.021"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19230-w"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2018.07.011"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2022.07.024"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-019-0431-2"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2022.03.004"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2014.02.004"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky354"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0032-3"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-019-0501-5"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtm.2019.11.009"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1089\/hgtb.2011.034"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23549-3"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/175164\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T19:01:19Z","timestamp":1704135679000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/175164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,2]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1,2]]},"published-print":{"date-parts":[[2024,1,2]]}},"alternative-id":["10.1172\/JCI175164"],"URL":"https:\/\/doi.org\/10.1172\/jci175164","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,2]]},"article-number":"e175164"}}