{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:29:23Z","timestamp":1790749763597,"version":"4.1.0"},"reference-count":37,"publisher":"American Society for Clinical Investigation","issue":"7","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union and Developing Countries Clinical Trials Partnership","award":["RIA2018SV-2311"],"award-info":[{"award-number":["RIA2018SV-2311"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Malaria transmission-blocking vaccines aim to interrupt the transmission of malaria from one person to another.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      The candidates R0.6C and ProC6C share the 6C domain of the\n                      <jats:italic>Plasmodium falciparum<\/jats:italic>\n                      sexual-stage antigen Pfs48\/45. R0.6C utilizes the glutamate-rich protein (GLURP) as a carrier, and ProC6C includes a second domain (Pfs230-Pro) and a short 36\u2013amino acid circumsporozoite protein (CSP) sequence. Healthy adults (\n                      <jats:italic>n<\/jats:italic>\n                      = 125) from a malaria-endemic area of Burkina Faso were immunized with 3 intramuscular injections, 4 weeks apart, of 30 \u03bcg or 100 \u03bcg R0.6C or ProC6C each adsorbed to Alhydrogel (AlOH) adjuvant alone or in combination with Matrix-M (15 \u03bcg or 50 \u03bcg, respectively). The allocation was random and double-blind for this phase I trial.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The vaccines were safe and well tolerated with no vaccine-related serious adverse events. A total of 7 adverse events, mild to moderate in intensity and considered possibly related to the study vaccines, were recorded. Vaccine-specific antibodies were highest in volunteers immunized with 100 \u03bcg ProC6C-AlOH with Matrix-M, and 13 of 20 (65%) individuals in the group showed greater than 80% transmission-reducing activity (TRA) when evaluated in the standard membrane feeding assay at 15 mg\/mL IgG. In contrast, R0.6C induced sporadic TRA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>All formulations were safe and well tolerated in a malaria-endemic area of Africa in healthy adults. The ProC6C-AlOH\/Matrix-M vaccine elicited the highest levels of functional antibodies, meriting further investigation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>TRIAL REGISTRATION<\/jats:title>\n                    <jats:p>Pan-African Clinical Trials Registry (https:\/\/pactr.samrc.ac.za) PACTR202201848463189.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>FUNDING<\/jats:title>\n                    <jats:p>The study was funded by the European and Developing Countries Clinical Trials Partnership (grant RIA2018SV-2311).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1172\/jci175707","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T14:46:19Z","timestamp":1706625979000},"source":"Crossref","is-referenced-by-count":22,"title":["A randomized first-in-human phase I trial of differentially adjuvanted Pfs48\/45 malaria vaccines in Burkinab\u00e9 adults"],"prefix":"10.1172","volume":"134","author":[{"given":"Alfred B.","family":"Tiono","sequence":"first","affiliation":[{"name":"Groupe de Recherche Action en Sant\u00e9 (GRAS), Ouagadougou, Burkina Faso."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan L.","family":"Plieskatt","sequence":"additional","affiliation":[{"name":"Department for Congenital Disorders, Statens Serum Institut (SSI), Copenhagen, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alphonse","family":"Ouedraogo","sequence":"additional","affiliation":[{"name":"Groupe de Recherche Action en Sant\u00e9 (GRAS), Ouagadougou, Burkina Faso."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben Idriss","family":"Soulama","sequence":"additional","affiliation":[{"name":"Groupe de Recherche Action en Sant\u00e9 (GRAS), Ouagadougou, Burkina Faso."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4455-2432","authenticated-orcid":true,"given":"Kazutoyo","family":"Miura","sequence":"additional","affiliation":[{"name":"Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith C.","family":"Bougouma","sequence":"additional","affiliation":[{"name":"Groupe de Recherche Action en Sant\u00e9 (GRAS), Ouagadougou, Burkina Faso."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Naghizadeh","sequence":"additional","affiliation":[{"name":"Department for Congenital Disorders, Statens Serum Institut (SSI), Copenhagen, Denmark."},{"name":"Centre for Medical Parasitology at Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aissata","family":"Barry","sequence":"additional","affiliation":[{"name":"Groupe de Recherche Action en Sant\u00e9 (GRAS), Ouagadougou, Burkina Faso."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Baptist B.","family":"Yaro","sequence":"additional","affiliation":[{"name":"Groupe de Recherche Action en Sant\u00e9 (GRAS), Ouagadougou, Burkina Faso."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sem","family":"Ezinmegnon","sequence":"additional","affiliation":[{"name":"Groupe de Recherche Action en Sant\u00e9 (GRAS), Ouagadougou, Burkina Faso."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noelie","family":"Henry","sequence":"additional","affiliation":[{"name":"Groupe de Recherche Action en Sant\u00e9 (GRAS), Ouagadougou, Burkina Faso."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebenezer Addo","family":"Ofori","sequence":"additional","affiliation":[{"name":"Department for Congenital Disorders, Statens Serum Institut (SSI), Copenhagen, Denmark."},{"name":"Centre for Medical Parasitology at Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bright","family":"Adu","sequence":"additional","affiliation":[{"name":"Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Accra, Ghana."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susheel K.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department for Congenital Disorders, Statens Serum Institut (SSI), Copenhagen, Denmark."},{"name":"Centre for Medical Parasitology at Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augustin","family":"Konkobo","sequence":"additional","affiliation":[{"name":"Groupe de Recherche Action en Sant\u00e9 (GRAS), Ouagadougou, Burkina Faso."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"L\u00f6vgren Bengtsson","sequence":"additional","affiliation":[{"name":"Novavax AB, Uppsala, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amidou","family":"Diarra","sequence":"additional","affiliation":[{"name":"Groupe de Recherche Action en Sant\u00e9 (GRAS), Ouagadougou, Burkina Faso."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Carnrot","sequence":"additional","affiliation":[{"name":"Novavax AB, Uppsala, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny M.","family":"Reimer","sequence":"additional","affiliation":[{"name":"Novavax AB, Uppsala, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amidou","family":"Ouedraogo","sequence":"additional","affiliation":[{"name":"Groupe de Recherche Action en Sant\u00e9 (GRAS), Ouagadougou, Burkina Faso."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moussa","family":"Tienta","sequence":"additional","affiliation":[{"name":"Malaria Research and Training Center, Mali\u2013National Institute of Allergy and Infectious Diseases International Center for Excellence in Research, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3835-5443","authenticated-orcid":true,"given":"Carole A.","family":"Long","sequence":"additional","affiliation":[{"name":"Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Issa N.","family":"Ouedraogo","sequence":"additional","affiliation":[{"name":"Groupe de Recherche Action en Sant\u00e9 (GRAS), Ouagadougou, Burkina Faso."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8555-9983","authenticated-orcid":true,"given":"Issaka","family":"Sagara","sequence":"additional","affiliation":[{"name":"Malaria Research and Training Center, Mali\u2013National Institute of Allergy and Infectious Diseases International Center for Excellence in Research, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sodiomon B.","family":"Sirima","sequence":"additional","affiliation":[{"name":"Groupe de Recherche Action en Sant\u00e9 (GRAS), Ouagadougou, Burkina Faso."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Theisen","sequence":"additional","affiliation":[{"name":"Department for Congenital Disorders, Statens Serum Institut (SSI), Copenhagen, Denmark."},{"name":"Centre for Medical Parasitology at Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2024,4,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002380"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/73062"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00199-4"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(93)90158-T"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1987.tb00511.x"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2006.05284.x"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1080\/14760584.2017.1276833"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01256"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.02.040"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1084\/jem.162.5.1460"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M700948200"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2014.03.020"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-021-00383-8"},{"issue":"3369","key":"B14","article-title":"A reproducible and scalable process for manufacturing a Pfs48\/45 based Plasmodium falciparum transmission-blocking vaccine","volume":"11","author":"Singh","year":"2020","journal-title":"Front Immunol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2016.03.016"},{"key":"B16","article-title":"40 years of Pfs48\/45 research as a transmission-blocking vaccine target of plasmodium falciparum malaria","volume":"tpmd211320","author":"Sauerwein","year":"2022","journal-title":"Am J Trop Med Hyg"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00943-0"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1084\/jem.158.3.976"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057909"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2020.03.018"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2023.2189885"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2017.05.054"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1186\/s12934-017-0710-0"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1172\/JCI146221"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-022-04173-y"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(23)00276-1"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-016-1515-z"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(22)00428-5"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit185"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1080\/14760584.2017.1355246"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050036"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3736\/jcim20100702"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1186\/s12934-018-0902-2"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.011268"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.02.022"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1715812114"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-021-00423-3"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/175707\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:33:54Z","timestamp":1779233634000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/175707"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,1]]},"references-count":37,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,4,1]]},"published-print":{"date-parts":[[2024,4,1]]}},"alternative-id":["10.1172\/JCI175707"],"URL":"https:\/\/doi.org\/10.1172\/jci175707","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,1]]},"article-number":"e175707"}}