{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:25:13Z","timestamp":1790130313209,"version":"4.0.1"},"reference-count":48,"publisher":"American Society for Clinical Investigation","issue":"10","license":[{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"vor","delay-in-days":57,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Cancer Institute","award":["R01 CA166593"],"award-info":[{"award-number":["R01 CA166593"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["U54 CA196519"],"award-info":[{"award-number":["U54 CA196519"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"U.S. Department of Defense","award":["W81XWH-22-1-0356)"],"award-info":[{"award-number":["W81XWH-22-1-0356)"]}]},{"DOI":"10.13039\/100001545","name":"Children\u2019s Tumor Foundation","doi-asserted-by":"crossref","award":["2022-01-008"],"award-info":[{"award-number":["2022-01-008"]}],"id":[{"id":"10.13039\/100001545","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,15]]},"abstract":"<jats:p>\n                    Neurofibromatosis type 1 (NF1) is caused by mutations in the\n                    <jats:italic>NF1<\/jats:italic>\n                    gene that encodes neurofibromin, a RAS GTPase\u2013activating protein. Inactivating\n                    <jats:italic>NF1<\/jats:italic>\n                    mutations cause hyperactivation of RAS-mediated signaling, resulting in the development of multiple neoplasms, including malignant peripheral nerve sheath tumors (MPNSTs). MPNSTs are an aggressive tumor and the main cause of mortality in patients with NF1. MPNSTs are difficult to resect and refractory to chemo- and radiotherapy, and no molecular therapies currently exist. Immune checkpoint blockade (ICB) is an approach to treat inoperable, undruggable cancers like MPNST, but successful outcomes require an immune cell\u2013rich tumor microenvironment. While MPNSTs are noninflamed \u201ccold\u201d tumors, here, we converted MPNSTs into T cell\u2013inflamed \u201chot\u201d tumors by activating stimulator of IFN genes (STING) signaling. Mouse genetic and human xenograft MPNST models treated with a STING agonist plus ICB exhibited growth delay via increased apoptotic cell death. This strategy offers a potential treatment regimen for MPNSTs.\n                  <\/jats:p>","DOI":"10.1172\/jci176748","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T12:00:52Z","timestamp":1710849652000},"source":"Crossref","is-referenced-by-count":14,"title":["STING activation reprograms the microenvironment to sensitize NF1-related malignant peripheral nerve sheath tumors for immunotherapy"],"prefix":"10.1172","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4366-9153","authenticated-orcid":true,"given":"Bandarigoda N.","family":"Somatilaka","sequence":"first","affiliation":[{"name":"Department of Dermatology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laasya","family":"Madana","sequence":"additional","affiliation":[{"name":"Department of Dermatology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Sadek","sequence":"additional","affiliation":[{"name":"Department of 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