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Here, we show that GLP-1 receptor\u2013positive (GLP-1R\u2013positive) neurons in the lateral septum (LS\n                    <jats:sup>GLP-1R<\/jats:sup>\n                    ) play a critical role in mediating the anorectic and weight-loss effects of liraglutide. LS\n                    <jats:sup>GLP-1R<\/jats:sup>\n                    neurons were robustly activated by liraglutide, and chemogenetic activation of these neurons dramatically suppressed feeding. Targeted knockdown of GLP-1 receptors within the LS, but not in the hypothalamus, substantially attenuated liraglutide\u2019s ability to inhibit feeding and lower body weight. The activity of LS\n                    <jats:sup>GLP-1R<\/jats:sup>\n                    neurons rapidly decreased during naturalistic feeding episodes, while synaptic inactivation of LS\n                    <jats:sup>GLP-1R<\/jats:sup>\n                    neurons diminished the anorexic effects triggered by liraglutide. Together, these findings offer critical insights into the functional role of LS\n                    <jats:sup>GLP-1R<\/jats:sup>\n                    neurons in the physiological regulation of energy homeostasis and delineate their instrumental role in mediating the pharmacological efficacy of liraglutide.\n                  <\/jats:p>","DOI":"10.1172\/jci178239","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T14:00:45Z","timestamp":1725285645000},"source":"Crossref","is-referenced-by-count":55,"title":["GLP-1R\u2013positive neurons in the lateral septum mediate the anorectic and weight-lowering effects of liraglutide in mice"],"prefix":"10.1172","volume":"134","author":[{"given":"Zijun","family":"Chen","sequence":"first","affiliation":[{"name":"Shenzhen Key Laboratory of Drug Addiction, Shenzhen Neher Neural Plasticity Laboratory, Shenzhen\u2013Hong Kong Institute of Brain Science, Shenzhen Institute of Advanced Technology, Chinese Academy of 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Technology, Chinese Academy of Sciences, Shenzhen, China."},{"name":"University of Chinese Academy of Sciences, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlong","family":"Xu","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Drug Addiction, Shenzhen Neher Neural Plasticity Laboratory, Shenzhen\u2013Hong Kong Institute of Brain Science, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China."},{"name":"Department of Neonatology, Shenzhen Maternity and Child Healthcare Hospital, The First School of Clinical Medicine, Southern Medical University, Shenzhen, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixiao","family":"Luo","sequence":"additional","affiliation":[{"name":"Hunan Province People\u2019s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, 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