{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T03:17:10Z","timestamp":1790479030007,"version":"4.1.0"},"reference-count":71,"publisher":"American Society for Clinical Investigation","issue":"10","license":[{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"vor","delay-in-days":58,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["P01AI116501"],"award-info":[{"award-number":["P01AI116501"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,15]]},"abstract":"<jats:p>\n                    Mechanisms that mediate allograft tolerance differ between organs. We have previously shown that Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    T cell\u2013enriched bronchus-associated lymphoid tissue (BALT) is induced in tolerant murine lung allografts and that these Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    cells suppress alloimmune responses locally and systemically. Here, we demonstrated that Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    cells that reside in tolerant lung allografts differed phenotypically and transcriptionally from those in the periphery and were clonally expanded. Using a mouse lung retransplant model, we showed that recipient Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    cells were continuously recruited to the BALT within tolerant allografts. We identified distinguishing features of graft-resident and newly recruited Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    cells and showed that graft-infiltrating Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    cells acquired transcriptional profiles resembling those of graft-resident Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    cells over time. Allografts underwent combined antibody-mediated rejection and acute cellular rejection when recruitment of recipient Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    cells was prevented. Finally, we showed that local administration of IL-33 could expand and activate allograft-resident Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    cells, providing a platform for the design of tolerogenic therapies for lung transplant recipients. Our findings establish graft-resident Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    cells as critical orchestrators of lung transplant tolerance and highlight the need to develop lung-specific immunosuppression.\n                  <\/jats:p>","DOI":"10.1172\/jci178975","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T12:00:14Z","timestamp":1742299214000},"source":"Crossref","is-referenced-by-count":10,"title":["Maintenance of graft tissue\u2013resident Foxp3+ cells is necessary for lung transplant tolerance in mice"],"prefix":"10.1172","volume":"135","author":[{"given":"Wenjun","family":"Li","sequence":"first","affiliation":[{"name":"Department of Surgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1598-9360","authenticated-orcid":true,"given":"Yuriko","family":"Terada","sequence":"additional","affiliation":[{"name":"Department of 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