{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T01:38:09Z","timestamp":1792546689279,"version":"4.5.0"},"reference-count":11,"publisher":"American Society for Clinical Investigation","issue":"12","license":[{"start":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T00:00:00Z","timestamp":1718582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,17]]},"abstract":"<jats:p>\n                    Bone fracture healing is a complex process with distinct phases: the inflammatory phase, the soft and hard callus formation, and the remodeling phase. In older individuals, bone healing can be delayed or disturbed, leading to non-union fractures at worst. The initial healing phases require communication between immune cells and osteoprogenitor cells. However, senescence in these cell types impedes fracture healing by unknown mechanisms. In this issue of the\n                    <jats:italic>JCI<\/jats:italic>\n                    , Saul et al. showed that two distinct senescent p21-expressing cell populations, an osteochondroprogenitor cell and a neutrophil subpopulation, intrinsically impair fracture healing in mice irrespective of age. Genetic ablation of p21-positive cells accelerated fracture healing, while removal of a different senescent cell population, p16-positive cells, made no difference. Conceptually, this view of senescence in fracture healing with a spotlight on osteoimmune cross-talk provides a promising rationale for therapies to boost bone repair at all ages.\n                  <\/jats:p>","DOI":"10.1172\/jci181974","type":"journal-article","created":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T14:00:39Z","timestamp":1718546439000},"source":"Crossref","is-referenced-by-count":24,"title":["Targeting senescent cells to boost bone fracture healing"],"prefix":"10.1172","volume":"134","author":[{"given":"Lorenz C.","family":"Hofbauer","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes and Bone Diseases, Department of Medicine III & University Center for Healthy Aging, Technische Universit\u00e4t Dresden Medical Center, Dresden, Germany."},{"name":"Center for Regenerative Therapies Dresden, Technische Universit\u00e4t Dresden, Dresden, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Baschant","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Bone Diseases, Department of Medicine III & University Center for Healthy Aging, Technische Universit\u00e4t Dresden Medical Center, Dresden, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Hofbauer","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Orthopedic, Trauma and Plastic Surgery Center, Technische Universit\u00e4t Dresden Medical Center, Dresden, Germany,"},{"name":"Nationales Zentrum f\u00fcr Tumorerkrankungen (NCT\/UCC), Technische Universit\u00e4t Dresden Medical Center, Dresden, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2024,6,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2014.164"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00289-8"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(21)00347-8"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4385"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.20-0529"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3978"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.135236"},{"issue":"12","key":"B8","doi-asserted-by":"crossref","DOI":"10.1172\/JCI179834","article-title":"Osteochondroprogenitor cells and neutrophils expressing p21 and senescence markers modulate fracture repair","volume":"134","author":"Saul","year":"2024","journal-title":"J Clin Invest"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1803"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1210\/en.2013-1960"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1607948"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/181974\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:29:55Z","timestamp":1779233395000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/181974"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,17]]},"references-count":11,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,6,17]]},"published-print":{"date-parts":[[2024,6,17]]}},"alternative-id":["10.1172\/JCI181974"],"URL":"https:\/\/doi.org\/10.1172\/jci181974","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,17]]},"article-number":"e181974"}}