{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T12:26:14Z","timestamp":1782563174839,"version":"3.54.5"},"reference-count":17,"publisher":"American Society for Clinical Investigation","issue":"12","license":[{"start":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T00:00:00Z","timestamp":1718582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,17]]},"abstract":"<jats:p>\n                    Obesity has reached pandemic proportion not only in the West but also in other countries around the world; it is now one of the leading causes of death worldwide. A Western diet is rich in saturated fats and provides more calories than necessary, contributing to the rise of the obesity rate. It also promotes the development of liver steatosis, insulin resistance, hyperglycemia, and hyperlipidemia. In this issue of the\n                    <jats:italic>JCI<\/jats:italic>\n                    , Goetzman and colleagues describe the effects of consuming dicarboxylic acids (DAs) as an alternative source of dietary fat. The 12-carbon dicarboxylic acid (DC12) was administered to mice at 20% of their daily caloric intake for nine weeks in place of triglycerides. Notably, the change in diet increased the metabolic rate, reduced body fat, reduced liver fat, and improved glucose tolerance. These findings highlight DAs as useful energy nutrients for combatting obesity and treating various metabolic disorders.\n                  <\/jats:p>","DOI":"10.1172\/jci181978","type":"journal-article","created":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T14:00:39Z","timestamp":1718546439000},"source":"Crossref","is-referenced-by-count":5,"title":["Dicarboxylic acids counteract the metabolic effects of a Western diet by boosting energy expenditure"],"prefix":"10.1172","volume":"134","author":[{"given":"Lidia","family":"Castagneto-Gissey","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences, Sapienza University of Rome, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan R.","family":"Bornstein","sequence":"additional","affiliation":[{"name":"Department of Medicine III, Universit\u00e4tsklinikum Carl Gustav Carus an der Technischen Universit\u00e4t Dresden, Dresden, Germany."},{"name":"Division of Diabetes & Nutritional Sciences, School of Cardiovascular and Metabolic Medicine and Sciences, King\u2019s College London, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geltrude","family":"Mingrone","sequence":"additional","affiliation":[{"name":"Division of Diabetes & Nutritional Sciences, School of Cardiovascular and Metabolic Medicine and Sciences, King\u2019s College London, London, United Kingdom."},{"name":"Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy."},{"name":"Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2024,6,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2006.tb00175.x"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI174186"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-0663"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2012.04177.x"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(97)00502-9"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1177\/014860719401800109"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00631.2005"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2010.01308.x"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-16938"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(19)30026-9"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2016.08.013"},{"key":"B12","unstructured":"National Diabetes Statistics Report 2020. https:\/\/www.cdc.gov\/diabetes\/pdfs\/data\/statistics\/national-diabetes-statistics-report.pdf Accessed May 9, 2024"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8227(96)01205-3"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.11.312"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000004"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00634-7"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2309000"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/181978\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:29:07Z","timestamp":1779233347000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/181978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,17]]},"references-count":17,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,6,17]]},"published-print":{"date-parts":[[2024,6,17]]}},"alternative-id":["10.1172\/JCI181978"],"URL":"https:\/\/doi.org\/10.1172\/jci181978","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,17]]},"article-number":"e181978"}}