{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:08:33Z","timestamp":1779235713372,"version":"3.51.4"},"reference-count":24,"publisher":"American Society for Clinical Investigation","issue":"13","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,1]]},"abstract":"<jats:p>\n                    Cystic fibrosis is a debilitating disease characterized by a poor medical prognosis due to devastating lung injury. Recent medical advances targeting the major genetic mutation \u0394F508 of the cystic fibrosis transmembrane conductance regulator (CFTR) protein have dramatically increased the lifespan of patients with this mutation. This development has led to major changes in the field and has pushed research beyond the ion transport nature of cystic fibrosis and toward multiorgan physiological reprogramming. In this issue of the\n                    <jats:italic>JCI<\/jats:italic>\n                    , Bae, Kim, and colleagues utilized a large animal pig model prior to the onset of disease. They revealed metabolic reprogramming and organ crosstalk that occurred prior to disease progression. These findings provide paradigm-shifting insight into this complex disease.\n                  <\/jats:p>","DOI":"10.1172\/jci182329","type":"journal-article","created":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T14:00:35Z","timestamp":1719756035000},"source":"Crossref","is-referenced-by-count":3,"title":["Cystic fibrosis\u2013related metabolic defects: crosstalk between ion channels and organs"],"prefix":"10.1172","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1908-4809","authenticated-orcid":true,"given":"Sunder","family":"Sims-Lucas","sequence":"first","affiliation":[{"name":"Department of Pediatrics, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9476-309X","authenticated-orcid":true,"given":"Eric S.","family":"Goetzman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2413-5415","authenticated-orcid":true,"given":"Thomas R.","family":"Kleyman","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"232","published-online":{"date-parts":[[2024,7,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00576-6"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.10"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005087.pub3"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00057003"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.75.103004.142532"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(19)30337-6"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3390\/life13071545"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3390\/children11020256"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32542-3"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.1019028"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a009563"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1172\/JCI174500"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1177\/0023677219868502"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1126\/science.1163600"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.702823"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1042\/CS20140059"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00014.2021"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2020101406"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00150.2012"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111482200"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.11.029"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3390\/nu13051580"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-45328-2_5"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1989.203"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/182329\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:28:43Z","timestamp":1779233323000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/182329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,1]]},"references-count":24,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2024,5,16]]},"published-print":{"date-parts":[[2024,7,1]]}},"alternative-id":["10.1172\/JCI182329"],"URL":"https:\/\/doi.org\/10.1172\/jci182329","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,1]]},"article-number":"e182329"}}