{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T14:26:32Z","timestamp":1782483992417,"version":"3.54.5"},"reference-count":22,"publisher":"American Society for Clinical Investigation","issue":"15","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:p>\n                    Migraines are a type of headache that occur with other neurological symptoms, but the pathophysiology remains unclear. In this issue of the\n                    <jats:italic>JCI<\/jats:italic>\n                    , Nelson-Maney and authors used constitutive and inducible knockouts of the CGRP receptor components, elegantly demonstrating an essential function of CGRP in modulating meningeal lymphatic vessels (MLVs) in migraine. CGRP was shown to induce rearrangement of membrane-bound gap junction proteins in MLVs, resulting in a reduced CSF flux into cervical lymph nodes. The authors also provided evidence of a primary role for CGRP in modulating neuro-immune function. Finally, by showing that blocking CGRP signaling in MLVs attenuated pain behavior associated with acute migraine in rodents, the authors provided a target for pharmacological blockade of CGRP in relation to primary headache disorders.\n                  <\/jats:p>","DOI":"10.1172\/jci182556","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T14:05:16Z","timestamp":1722434716000},"source":"Crossref","is-referenced-by-count":7,"title":["Meningeal lymphatic vessel dysfunction driven by CGRP signaling causes migraine-like pain in mice"],"prefix":"10.1172","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3397-0292","authenticated-orcid":true,"given":"Jean-Leon","family":"Thomas","sequence":"first","affiliation":[{"name":"Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA."},{"name":"Paris Brain Institute, Universit\u00e9 Pierre et Marie Curie Paris 06 UMRS1127, Sorbonne Universit\u00e9, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle A.D.","family":"Schindler","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA."},{"name":"Neurology Service and"},{"name":"Headache Center of Excellence, Veterans Affairs Connecticut Healthcare Sytem, West Haven, Connecticut, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1105-6910","authenticated-orcid":true,"given":"Christopher","family":"Gottschalk","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2024,8,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI175616"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2005.01016.x"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410330109"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a6cb72"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410280213"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63851-5"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20180528"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.26.7.2511-2518.2006"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-080422-105509"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/313054a0"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00034.2013"},{"key":"B12","article-title":"Meningeal lymphatics in central nervous system diseases","author":"Salvador","journal-title":"Annu Rev Neurosci"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.104987"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1172\/JCI90603"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0368-8"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20220035"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3390-16.2017"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23604"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-018-0933-4"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-024-05141-2"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-024-01741-2"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26842"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/182556\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:27:07Z","timestamp":1779233227000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/182556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,1]]},"references-count":22,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2024,6,17]]},"published-print":{"date-parts":[[2024,8,1]]}},"alternative-id":["10.1172\/JCI182556"],"URL":"https:\/\/doi.org\/10.1172\/jci182556","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,1]]},"article-number":"e182556"}}