{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:24:08Z","timestamp":1791908648805,"version":"4.3.4"},"reference-count":68,"publisher":"American Society for Clinical Investigation","issue":"2","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":56,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Cancer Institute","award":["R01CA272946"],"award-info":[{"award-number":["R01CA272946"]}]},{"name":"National Cancer Institute","award":["R01CA266529"],"award-info":[{"award-number":["R01CA266529"]}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","award":["R01DK070910"],"award-info":[{"award-number":["R01DK070910"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Cancer Institute","award":["R01CA266342"],"award-info":[{"award-number":["R01CA266342"]}]},{"name":"National Cancer Institute","award":["R01CA165065"],"award-info":[{"award-number":["R01CA165065"]}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"crossref","award":["R01NS061817"],"award-info":[{"award-number":["R01NS061817"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"crossref","award":["R01NS076511"],"award-info":[{"award-number":["R01NS076511"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["P01HL114453"],"award-info":[{"award-number":["P01HL114453"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["U01AI156924"],"award-info":[{"award-number":["U01AI156924"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["U01AI156923"],"award-info":[{"award-number":["U01AI156923"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["R01AI145406"],"award-info":[{"award-number":["R01AI145406"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"crossref","award":["R01AR067746"],"award-info":[{"award-number":["R01AR067746"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100003185","name":"National Psoriasis Foundation","doi-asserted-by":"crossref","award":["Discovery Grant"],"award-info":[{"award-number":["Discovery Grant"]}],"id":[{"id":"10.13039\/100003185","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,16]]},"abstract":"<jats:p>\n                    Dysregulations of epithelial-immune interactions frequently culminate in chronic inflammatory diseases of the skin, lungs, kidneys, and gastrointestinal tract. Yet, the intraepithelial processes that initiate and perpetuate inflammation in these organs are poorly understood. Here, by utilizing redox lipidomics we identified ferroptosis-associated peroxidation of polyunsaturated phosphatidylethanolamines in the epithelia of patients with asthma, cystic fibrosis, psoriasis, and renal failure. Focusing on psoriasis as a disease model, we used high-resolution mass spectrometry imaging and identified keratin 14\u2013expressing (K14-expressing) keratinocytes executing a ferroptotic death program in human psoriatic skin. Psoriatic phenotype with characteristic Th1\/Th17 skin and extracutaneous immune responses was initiated and maintained in a murine model designed to actuate ferroptosis in a fraction of K14\n                    <jats:sup>+<\/jats:sup>\n                    glutathione peroxidase 4\u2013deficient (Gpx4-deficient) epidermal keratinocytes. Importantly, an antiferroptotic agent, liproxstatin-1, was as effective as clinically relevant biological IL-12\/IL-23\/TNF-\u03b1\u2013targeting therapies or the depletion of T cells in completely abrogating molecular, biochemical, and morphological features of psoriasis. As ferroptosis in select epidermal keratinocytes triggers and sustains a pathological psoriatic multiorgan inflammatory circuit, we suggest that strategies targeting ferroptosis or its causes may be effective in preventing or ameliorating a variety of chronic inflammatory diseases.\n                  <\/jats:p>","DOI":"10.1172\/jci183219","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T12:00:16Z","timestamp":1732190416000},"source":"Crossref","is-referenced-by-count":29,"title":["Ferroptosis of select skin epithelial cells initiates and maintains chronic systemic immune-mediated psoriatic disease"],"prefix":"10.1172","volume":"135","author":[{"given":"Kavita","family":"Vats","sequence":"first","affiliation":[{"name":"Department of Dermatology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Tian","sequence":"additional","affiliation":[{"name":"Center for Free Radical and Antioxidant Health, Department of Environmental Health and Occupational Health, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunal","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Dermatology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulia Y.","family":"Tyurina","sequence":"additional","affiliation":[{"name":"Center for Free Radical and Antioxidant Health, Department of Environmental Health and Occupational Health, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis J.","family":"Sparvero","sequence":"additional","affiliation":[{"name":"Center for Free Radical and Antioxidant Health, Department of Environmental Health and Occupational Health, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3474-1697","authenticated-orcid":true,"given":"Vladimir A.","family":"Tyurin","sequence":"additional","affiliation":[{"name":"Center for Free Radical and Antioxidant Health, Department of Environmental Health and Occupational Health, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9847-7581","authenticated-orcid":true,"given":"Oleg","family":"Kruglov","sequence":"additional","affiliation":[{"name":"Department of Dermatology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3822-0469","authenticated-orcid":true,"given":"Alexander","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiefei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicia","family":"Green","sequence":"additional","affiliation":[{"name":"Biomolecular Imaging Lab, Rosalind Franklin Institute, Didcot, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5731-122X","authenticated-orcid":true,"given":"Svetlana N.","family":"Samovich","sequence":"additional","affiliation":[{"name":"Center for Free Radical and Antioxidant Health, Department of Environmental Health and Occupational Health, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansuman","family":"Chattopadhyay","sequence":"additional","affiliation":[{"name":"Molecular Biology Information Service, Health Sciences Library System,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Murray","sequence":"additional","affiliation":[{"name":"Department of Dermatology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vrusha K.","family":"Shah","sequence":"additional","affiliation":[{"name":"School of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia R.","family":"Mathers","sequence":"additional","affiliation":[{"name":"Department of Dermatology,"},{"name":"Department of Immunology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uma R.","family":"Chandran","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0893-1155","authenticated-orcid":true,"given":"Joseph M.","family":"Pilewski","sequence":"additional","affiliation":[{"name":"Department of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1995-2653","authenticated-orcid":true,"given":"John A.","family":"Kellum","sequence":"additional","affiliation":[{"name":"Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7761-9109","authenticated-orcid":true,"given":"Sally E.","family":"Wenzel","sequence":"additional","affiliation":[{"name":"Center for Free Radical and Antioxidant Health, Department of Environmental Health and Occupational Health, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00fclya","family":"Bay\u0131r","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Critical Care and Hospital Medicine, Redox Health Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7245-1885","authenticated-orcid":true,"given":"Valerian E.","family":"Kagan","sequence":"additional","affiliation":[{"name":"Center for Free Radical and Antioxidant Health, Department of Environmental Health and Occupational Health, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri L.","family":"Bunimovich","sequence":"additional","affiliation":[{"name":"Department of Dermatology,"},{"name":"Department of Immunology,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2024,11,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI151685"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI99490"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.09.044"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4006"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0256-2"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20061475"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1159\/000495291"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11020282"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10539.x"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-021-01441-9"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2018.05.018"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-04284-5"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2022.07.041"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-022-03566-6"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.12.010"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b09913"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1093\/database\/baaa021"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.28"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23094983"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18075-7"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.09.006"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.804824"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202314710"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1369\/0022155418788117"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201600036"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1021\/ac5011876"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.0c05311"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201814256"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.335174"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.132747"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3390\/genes11101155"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/ng.311"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802999"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-017-0415-3"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119766"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018266"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/nm1162"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20060244"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084634"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.06.044"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002737"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-015-0208-5"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.12.018"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3066"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2020.101068"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3390\/ijms221910777"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-00441-1"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-022-00940-8"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20160258"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-001369"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05443-0"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.102143"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.52"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23158575"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2256-z"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10699.x"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-00996-0"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.03.032"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-012-9479-5"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2021.111153"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.41082"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.06.037"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013066"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)64849-5"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1002\/recl.19610801102"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102650"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v086.i08"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-020-01023-0"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/183219\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T22:47:53Z","timestamp":1779230873000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/183219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,21]]},"references-count":68,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,1,16]]},"published-print":{"date-parts":[[2025,1,16]]}},"alternative-id":["10.1172\/JCI183219"],"URL":"https:\/\/doi.org\/10.1172\/jci183219","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,21]]},"article-number":"e183219"}}