{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:09:05Z","timestamp":1779232145774,"version":"3.51.4"},"reference-count":27,"publisher":"American Society for Clinical Investigation","issue":"17","license":[{"start":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T00:00:00Z","timestamp":1725321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,3]]},"abstract":"<jats:p>\n                    Sarcoidosis is an inflammatory disease characterized by immune cell\u2013rich granulomas that form in multiple organs. In this issue of the\n                    <jats:italic>JCI<\/jats:italic>\n                    , Sati and colleagues used scRNA-seq and spatial transcriptomics of skin samples from patients with sarcoidosis and non-sarcoidosis granulomatous disease to identify upregulation of a stromal-immune CXCL12\/CXCR4 axis and accumulation of type 1 innate lymphoid cells (ILC1s) in sarcoidosis. The accumulation of ILC1s in skin and blood was specific to patients with sarcoidosis and not observed in other granulomatous diseases. The authors used a mouse model of lung granuloma to show that ILCs contribute to granuloma formation and that blockade of CXCR4 reduced the formation of granulomas, providing a proof of concept that sarcoidosis may be treated by CXCR4 blockade to prevent the progression of disease in patients. These results suggest ILC1s could serve as a diagnostic biomarker in sarcoidosis and a potential therapeutic target.\n                  <\/jats:p>","DOI":"10.1172\/jci183708","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T14:00:45Z","timestamp":1725285645000},"source":"Crossref","is-referenced-by-count":2,"title":["Type 1 innate lymphoid cells: a biomarker and therapeutic candidate in sarcoidosis"],"prefix":"10.1172","volume":"134","author":[{"given":"Inchul","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Dermatology,"},{"name":"Black Family Stem Cell Institute,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew L.","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Dermatology,"},{"name":"Black Family Stem Cell Institute,"},{"name":"Department of Oncological Sciences,"},{"name":"Department of Cell, Developmental and Regenerative Biology, and"},{"name":"Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"232","published-online":{"date-parts":[[2024,9,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI175264"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200402-249OC"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2008.03.007"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071714"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2018.10.004"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5261.1165"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(21)00030-8"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60680-7"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/nri3211"},{"issue":"17","key":"B10","doi-asserted-by":"crossref","DOI":"10.1172\/JCI178711","article-title":"Recruitment of CXCR4+ type 1 innate lymphoid cells distinguishes sarcoidosis from other skin granulomatous diseases","volume":"134","author":"Sati","year":"2024","journal-title":"J Clin Invest"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.7.5130"},{"issue":"35","key":"B12","doi-asserted-by":"crossref","first-page":"11024","DOI":"10.1073\/pnas.1503315112","article-title":"IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs","volume":"112","author":"Barone","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-08-594796"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20140457"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080752"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00094-2"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80453-5"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.01.014"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.08.043"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2023.02.040"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-00956-8"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-022-01409-2"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2021.12.014"},{"issue":"10","key":"B24","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/s41576-021-00370-8","article-title":"Integrating single-cell and spatial transcriptomics to elucidate intercellular tissue dynamics","volume":"22","author":"Longom","year":"2021","journal-title":"Nat Rev Genet"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-024-01792-2"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-43458-x"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.03.013"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/183708\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:02:57Z","timestamp":1779231777000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/183708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,3]]},"references-count":27,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2024,9,3]]},"published-print":{"date-parts":[[2024,9,3]]}},"alternative-id":["10.1172\/JCI183708"],"URL":"https:\/\/doi.org\/10.1172\/jci183708","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,3]]},"article-number":"e183708"}}