{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:39:09Z","timestamp":1791877149702,"version":"4.3.4"},"reference-count":56,"publisher":"American Society for Clinical Investigation","issue":"20","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":71,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014718","name":"Innovative Research Group Project of the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82370176"],"award-info":[{"award-number":["82370176"]}],"id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Key Research and Development Program of Hubei Province","award":["2023BCB025"],"award-info":[{"award-number":["2023BCB025"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,15]]},"abstract":"<jats:p>\n                    Acute myeloid leukemia (AML) is the most common hematological malignancy. Leukemia stem cells exhibit high levels of oxidative stress, with ROS being the primary products of this stress, inducing the expression of c-JUN activation domain-binding protein 1 (Jab1). Previous studies have demonstrated that Jab1, as a transcriptional coactivator of c-JUN, promotes the malignant progression of AML under oxidative stress. However, its role in immune evasion is still under investigation. Here, we observed that knocking out Jab1 reduced the expression of immune checkpoints in vivo, effectively overcoming the immune evasion of AML. Interestingly, the deletion of Jab1 had no impact on the maturation of normal hematopoietic cells in mice. Mechanistically, Jab1 directly activated IGF2BP3 by driving the transcription factor c-JUN, consequently modulated the m\n                    <jats:sup>6<\/jats:sup>\n                    A modification of LILRB4 mRNA, and promoted immune evasion in AML. Finally, CSN5i-3 effectively disrupted the signaling pathway mediated by Jab1, thereby restoring cellular immune surveillance and halting the progression of AML. Thus, our results highlight the functional role of Jab1 in supporting AML survival and support the development of targeted therapeutic strategies.\n                  <\/jats:p>","DOI":"10.1172\/jci183761","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T16:38:48Z","timestamp":1754411928000},"source":"Crossref","is-referenced-by-count":9,"title":["Jab1 promotes immune evasion and progression in acute myeloid leukemia models under oxidative stress"],"prefix":"10.1172","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5877-1786","authenticated-orcid":true,"given":"Nan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, China."},{"name":"Department of Hematology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 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