{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:15:37Z","timestamp":1787764537897,"version":"build-2784847793"},"reference-count":24,"publisher":"American Society for Clinical Investigation","issue":"17","license":[{"start":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T00:00:00Z","timestamp":1725321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,3]]},"abstract":"<jats:p>\n                    Lyme disease, caused by\n                    <jats:italic>Borrelia burgdorferi<\/jats:italic>\n                    (\n                    <jats:italic>Bb<\/jats:italic>\n                    ), can progress to Lyme arthritis (LA). While most patients with LA respond successfully to antibiotic therapy, a small percentage fail to improve, a condition known as antibiotic-refractory Lyme arthritis (ARLA). While T cell responses are known to drive ARLA, molecular mechanisms for ARLA remain unknown. In this issue of the\n                    <jats:italic>JCI<\/jats:italic>\n                    , Dirks et al. isolated disease-specific Th cells from patients with ARLA residing in Germany. A distinct TCR-\u03b2 motif distinguished ARLA from other rheumatic diseases. Notably, the TCR-\u03b2 motif was linked predominantly to HLA-DRB1*11 or 13 alleles, which differed from alleles in patients from North America. It also mapped primarily to T peripheral helper (Tph) cells, as opposed to classical Th1 cells. These findings provide a roadmap explaining how T cell responses necessary for control of an infection can, despite antibiotic therapy, drive a disadvantageous T cell response, resulting in a postinfectious, inflammatory arthritis.\n                  <\/jats:p>","DOI":"10.1172\/jci184109","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T14:00:45Z","timestamp":1725285645000},"source":"Crossref","is-referenced-by-count":6,"title":["Wider recognition and greater understanding of postinfectious, antibiotic-refractory Lyme arthritis"],"prefix":"10.1172","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5268-9853","authenticated-orcid":true,"given":"Allen C.","family":"Steere","sequence":"first","affiliation":[{"name":"Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob E.","family":"Lemieux","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2024,9,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780200102"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-107-5-725"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/art.22131"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1002\/art.30384"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/BF01711648"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3201\/eid2708.204763"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2018.09.007"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/art.39866"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1172\/JCI179391"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20052471"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-021-00648-5"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/ng.1076"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/nature20810"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/art.41913"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/art.34383"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1002\/art.37910"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1172\/JCI161170"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiae164"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.108804"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1002\/art.42408"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03492.x"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1002\/art.24812"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1011243"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-018-0070-0"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/184109\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:03:37Z","timestamp":1779231817000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/184109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,3]]},"references-count":24,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2024,9,3]]},"published-print":{"date-parts":[[2024,9,3]]}},"alternative-id":["10.1172\/JCI184109"],"URL":"https:\/\/doi.org\/10.1172\/jci184109","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,3]]},"article-number":"e184109"}}