{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:47:23Z","timestamp":1790153243992,"version":"4.0.1"},"reference-count":89,"publisher":"American Society for Clinical Investigation","issue":"3","license":[{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"vor","delay-in-days":55,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fondation pour l\u2019Aide \u00e0 la recherche sur la Scl\u00e9rose en Plaques","award":["ARSEP 2016\/2020"],"award-info":[{"award-number":["ARSEP 2016\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,3]]},"abstract":"<jats:p>\n                    Multiple sclerosis (MS) is an autoimmune disease that affects the CNS, the pathophysiology of which remains unclear and for which there is no definitive cure. Antimicrobial peptides (AMPs) are immunomodulatory molecules expressed in various tissues, including the CNS. Here, we investigated whether the cathelicidin-related AMP (CRAMP) modulated the development of experimental autoimmune encephalomyelitis (EAE), a mouse model of MS. We showed that, at an early stage, CNS-recruited neutrophils produced neutrophil extracellular traps (NETs) rich in CRAMP that were required for EAE initiation. NET-associated CRAMP stimulated IL-6 production by dendritic cells via the cGAS\/STING pathway, thereby promoting encephalitogenic Th17 response. However, at a later disease stage, neurons also expressed CRAMP that reduced EAE severity.\n                    <jats:italic>Camp<\/jats:italic>\n                    knockdown in neurons led to disease exacerbation, while local injection of CRAMP\n                    <jats:sub>1\u201339<\/jats:sub>\n                    at the peak of EAE promoted disease remission. In vitro, CRAMP\n                    <jats:sub>1\u201339<\/jats:sub>\n                    regulated the activation of microglia and astrocytes through the formyl peptide receptor (FPR) 2. Finally, administration of butyrate, a gut microbiota-derived metabolite, stimulated the expression of neural CRAMP via the free fatty acids receptors 2\/3 (FFAR2\/3), and prevented EAE. This study shows that CRAMP produced by different cell types has opposing effects on neuroinflammation, offering therapeutic opportunities for MS and other neuroinflammatory disorders.\n                  <\/jats:p>","DOI":"10.1172\/jci184502","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T12:01:49Z","timestamp":1733832109000},"source":"Crossref","is-referenced-by-count":25,"title":["Cathelicidin antimicrobial peptide expression in neutrophils and neurons antagonistically modulates neuroinflammation"],"prefix":"10.1172","volume":"135","author":[{"given":"Subash Chand","family":"Verma","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, CNRS, INSERM, Institut Necker Enfants Malades\u2013INEM, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"En\u00e9e","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, CNRS, INSERM, Institut Necker Enfants Malades\u2013INEM, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanchanadevi","family":"Manasse","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, CNRS, INSERM, Institut Necker Enfants Malades\u2013INEM, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feriel","family":"Rebhi","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, CNRS, INSERM, Institut Necker Enfants Malades\u2013INEM, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axelle","family":"Penc","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, CNRS, INSERM, Institut Necker Enfants Malades\u2013INEM, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Romeo-Guitart","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, CNRS, INSERM, Institut Necker Enfants Malades\u2013INEM, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuc","family":"Bui Thi","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, CNRS, INSERM, Institut Necker Enfants Malades\u2013INEM, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7386-2769","authenticated-orcid":true,"given":"Matthias","family":"Titeux","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Imagine Institute, INSERM U1163, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Oury","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, CNRS, INSERM, Institut Necker Enfants Malades\u2013INEM, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Fillatreau","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, CNRS, INSERM, Institut Necker Enfants Malades\u2013INEM, Paris, France."},{"name":"APHP, H\u00f4pital Necker-Enfants Malades, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Liblau","sequence":"additional","affiliation":[{"name":"Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), CNRS, INSERM, Universit\u00e9 Paul-Sabatier de Toulouse (UPS), Toulouse, France."},{"name":"Department of Immunology, Toulouse University Hospital, Toulouse, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Diana","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, CNRS, INSERM, Institut Necker Enfants Malades\u2013INEM, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2024,12,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10554"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.08.021"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.2689"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00740"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2012.09.007"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3168"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.01.011"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1980.tb05991.x"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/nri3228"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.12.272"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.29"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2015.03.002"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001180"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3042"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aax7942"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.02077"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-010-0089-7"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2022.843790"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03081.x"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01043-06"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e31818b4801"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1100\/2012\/905785"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3390\/cells9010043"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2009.10.004"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1159\/000353645"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-017-0190-1"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20141015"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-022-00787-0"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1083242"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000200127"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21533-5"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.01902"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2005.11.014"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12612"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01881"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01137"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3390\/jcm7120511"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2011.11.009"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2006.05.026"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.96882"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12147"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181ce5db0"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000001149"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-020-02132-y"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400401"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.161.11.6421"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202250059"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20072404"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1403063"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.1.566"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.7.873"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092385"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2023.10.035"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-22409-3"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701391"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101102"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.046755"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110880"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3001554"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5008"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-017-1555-z"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-019-0058-8"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2013.08.011"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.07.013"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2015.04.006"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1038\/srep37789"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1002\/glia.24227"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2009.19"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.3390\/cells11233886"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1007\/s43440-021-00271-x"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2018.06.020"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-7-55"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.3390\/cells10092373"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242115996"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-020-00518-2"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.5.735"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00818-09"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-022-00697-8"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.09.007"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-022-01364-2"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1038\/nature12726"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173032"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-021-01596-8"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aau4760"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X20910533"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1973.224.6.1450"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(79)90109-8"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/547967"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.4110\/in.2020.20.e15"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/184502\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T22:49:00Z","timestamp":1779230940000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/184502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,10]]},"references-count":89,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,12,2]]},"published-print":{"date-parts":[[2025,2,3]]}},"alternative-id":["10.1172\/JCI184502"],"URL":"https:\/\/doi.org\/10.1172\/jci184502","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,10]]},"article-number":"e184502"}}