{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:26:23Z","timestamp":1791332783520,"version":"4.3.1"},"reference-count":24,"publisher":"American Society for Clinical Investigation","issue":"19","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:p>\n                    Ineffective recovery from pneumonia can lead to interstitial lung disease characterized by aberrant epithelial cells in fibrotic regions. In this issue of the\n                    <jats:italic>JCI<\/jats:italic>\n                    , Lin et al. define molecular pathways leading to the development and persistence of keratin 5\n                    <jats:sup>+<\/jats:sup>\n                    (Krt5\n                    <jats:sup>+<\/jats:sup>\n                    ) epithelial cells in the alveolar parenchyma when mice struggle to recover from influenza infection. The receptor for IFN-\u03b3 on lung epithelium was essential for the formation of aberrant Krt5\n                    <jats:sup>+<\/jats:sup>\n                    cells and fibrotic lung disease. The transcription factor Yes-associated protein 1 (YAP) was necessary for persistence of these Krt5\n                    <jats:sup>+<\/jats:sup>\n                    cells, and IFN-\u03b3 activated YAP in lung epithelial cells via JAK, focal adhesion kinase (FAK), and Src kinases. These findings establish a targetable pathway underlying some of the pulmonary postacute sequelae of pneumonia.\n                  <\/jats:p>","DOI":"10.1172\/jci185072","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T14:00:47Z","timestamp":1727704847000},"source":"Crossref","is-referenced-by-count":7,"title":["IFN-\u03b3 and YAP lead epithelial cells astray after severe respiratory infection"],"prefix":"10.1172","volume":"134","author":[{"given":"Bradley E.","family":"Hiller","sequence":"first","affiliation":[{"name":"Pulmonary Center,"},{"name":"Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4042-3169","authenticated-orcid":true,"given":"Joseph P.","family":"Mizgerd","sequence":"additional","affiliation":[{"name":"Pulmonary Center,"},{"name":"Department of Medicine,"},{"name":"Department of Virology, Immunology, and Microbiology, and"},{"name":"Department of Biochemistry and Cell Biology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2024,10,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00032.2017"},{"key":"B2","article-title":"Long covid defined","author":"Ely","journal-title":"N Engl J Med"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201801-0139WS"},{"key":"B4","article-title":"Post-infectious pulmonary complications: establishing research priorities to advance the field. 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