{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T13:51:36Z","timestamp":1780667496991,"version":"3.54.1"},"reference-count":62,"publisher":"American Society for Clinical Investigation","issue":"7","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:p>\n                    Cytokines mediating epithelial and immune cell interactions modulate mucosal healing\u2014a process that goes awry with chronic inflammation as in inflammatory bowel disease. TNFSF13 is a cytokine important for B cell maturation and function, but roles for epithelial TNFSF13 and putative contribution to inflammatory bowel disease are poorly understood. We evaluated functional consequences of a novel monoallelic\n                    <jats:italic>TNFSF13<\/jats:italic>\n                    variant using biopsies, tissue-derived colonoids and induced pluripotent stem cell (iPSC)-derived colon organoids.\n                    <jats:italic>TNFSF13<\/jats:italic>\n                    variant colonoids exhibited a &gt;50% reduction in secreted TNFSF13, increased epithelial proliferation, and reduced apoptosis, which was confirmed in iPSC-derived colon organoids. Single cell RNA-sequencing and flow cytometry suggested FAS as the predominant colonic epithelial receptor for TNFSF13, which was confirmed by co-immunoprecipitation and binding assays. Imaging mass cytometry revealed an increase in epithelial-associated B cells in\n                    <jats:italic>TNFSF13<\/jats:italic>\n                    variant colon tissue sections. Finally,\n                    <jats:italic>TNFSF13<\/jats:italic>\n                    variant colonoids co-cultured with memory B cells demonstrated a reduction in immunoglobulin-producing plasma cells compared to control colonoid cocultures. Our findings support a role for epithelial TNFSF13 as a regulator of colonic epithelial growth and epithelial crosstalk with B cells.\n                  <\/jats:p>","DOI":"10.1172\/jci186032","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T18:00:57Z","timestamp":1774980057000},"source":"Crossref","is-referenced-by-count":1,"title":["TNFSF13 insufficiency disrupts human colonic epithelial cell growth and associated B cell dynamics"],"prefix":"10.1172","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6171-0722","authenticated-orcid":true,"given":"Xianghui","family":"Ma","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaneice K.","family":"Nettleford","sequence":"additional","affiliation":[{"name":"Division of 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