{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T09:17:04Z","timestamp":1782983824893,"version":"3.54.5"},"reference-count":23,"publisher":"American Society for Clinical Investigation","issue":"22","license":[{"start":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T00:00:00Z","timestamp":1731628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,15]]},"abstract":"<jats:p>\n                    Lung megakaryocytes (Mks) are a unique subset of Mks that are distinct from their bone marrow counterparts. Recent evidence suggests that lung Mks favor an immune phenotype, but have unclear contributions to the total platelet mass. In this issue of the\n                    <jats:italic>JCI<\/jats:italic>\n                    , Livada et al. used an array of complementary in vivo labeling and tracing models in mice to investigate a longstanding question of where lung Mks are derived. By combining these models with stressed conditions, the authors assessed the contribution of lung Mks to total platelet counts in a homeostatic and thrombocytopenic state. Mks were minor contributors to the circulating pool of platelets during homeostasis but increased output during thrombocytopenia. These findings add critical understanding to the development of lung Mks and demonstrate the dynamic potential of these specialized cells to respond to thrombocytopenia.\n                  <\/jats:p>","DOI":"10.1172\/jci186111","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T14:00:36Z","timestamp":1731592836000},"source":"Crossref","is-referenced-by-count":4,"title":["The lung is a megakaryocyte outpost that can defend against thrombocytopenic attack"],"prefix":"10.1172","volume":"134","author":[{"given":"Anthony K.","family":"Yeung","sequence":"first","affiliation":[{"name":"Department of Pediatrics, UCSF, San Francisco, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George J.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, Massachusetts, USA."},{"name":"Section of Hematology and Medical Oncology, Boston University School of Medicine, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2024,11,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpth.2023.100053"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00017.2019"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1172\/JCI137377"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020002843"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021010697"},{"issue":"22","key":"B6","doi-asserted-by":"crossref","DOI":"10.1172\/JCI181111","article-title":"Long-lived lung megakaryocytes contribute to platelet recovery in thrombocytopenia models","volume":"134","author":"Livada","year":"2024","journal-title":"J Clin Invest"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022009022"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1083339"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1029223"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.04.018"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/nature21706"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-11-742684"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1983.00201.x-i1"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1025945"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39598-9"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022008347"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-11-393991"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2013.05.007"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3706"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3707"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/nature25168"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/nature25455"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2024.02.006"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/186111\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:00:52Z","timestamp":1779231652000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/186111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,15]]},"references-count":23,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2024,11,15]]},"published-print":{"date-parts":[[2024,11,15]]}},"alternative-id":["10.1172\/JCI186111"],"URL":"https:\/\/doi.org\/10.1172\/jci186111","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,15]]},"article-number":"e186111"}}