{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T11:34:36Z","timestamp":1784374476064,"version":"3.55.0"},"reference-count":20,"publisher":"American Society for Clinical Investigation","issue":"19","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,1]]},"DOI":"10.1172\/jci186231","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T14:00:47Z","timestamp":1727704847000},"source":"Crossref","is-referenced-by-count":3,"title":["The arc of discovery, from the description of cystic fibrosis to effective treatments"],"prefix":"10.1172","volume":"134","author":[{"given":"Michael J.","family":"Welsh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2024,10,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1938.01980140114013"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.12.5.549"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104498"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/301421a0"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110894"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.18.6167"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1126\/science.2475911"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/347358a0"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90398-X"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1126\/science.1712984"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90353-R"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/358761a0"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2100665"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2216474"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1172\/JCI7935"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119676"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1172\/JCI176328"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1172\/JCI44235"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1300109"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1172\/JCI174500"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/186231\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:13:04Z","timestamp":1779232384000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/186231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,1]]},"references-count":20,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2024,10,1]]},"published-print":{"date-parts":[[2024,10,1]]}},"alternative-id":["10.1172\/JCI186231"],"URL":"https:\/\/doi.org\/10.1172\/jci186231","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,1]]},"article-number":"e186231"}}