{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:07:01Z","timestamp":1779232021353,"version":"3.51.4"},"reference-count":15,"publisher":"American Society for Clinical Investigation","issue":"1","license":[{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,2]]},"abstract":"<jats:p>\n                    Similarly to acute intestinal helminth infection, several conditions of chronic eosinophilic type 2 inflammation of mucosal surfaces, including asthma and eosinophilic esophagitis, feature robust expansions of intraepithelial mast cells (MCs). Also the hyperplastic mucosa of nasal polyposis in the context of chronic rhinosinusitis, with or without COX1 inhibitor intolerance, contains impressive numbers of intraepithelial MCs. In this issue of the\n                    <jats:italic>JCI<\/jats:italic>\n                    , Derakhshan et al. elucidate the heterogeneity of MCs in nasal polyposis and identify a transcriptional signature of TGF-\u03b2 target genes expressed by the intraepithelial MC population. These MCs displayed effector functions that implicate them as pathogenetic contributors. TGF-\u03b2 directed differentiation of similar MC populations also in vitro. These findings extend the emerging concept of TGF-\u03b2 as a driver of type 2 inflammation at barrier surfaces.\n                  <\/jats:p>","DOI":"10.1172\/jci186337","type":"journal-article","created":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T14:00:42Z","timestamp":1735740042000},"source":"Crossref","is-referenced-by-count":2,"title":["TGF-\u03b2 drives differentiation of intraepithelial mast cells in inflamed airway mucosa"],"prefix":"10.1172","volume":"135","author":[{"given":"Axel","family":"Roers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"232","published-online":{"date-parts":[[2025,1,2]]},"reference":[{"issue":"22","key":"B1","article-title":"Human intraepithelial mast cell differentiation and effector function are directed by TGF-\u03b2 signaling","volume":"134","author":"Derakhshan","year":"2024","journal-title":"J Clin Invest"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2014.91"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abb7221"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.07.017"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.07.007"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1712125"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20200321"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.12.010"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.03.016"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201906-1215OC"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2024.03.017"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1613125"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacig.2024.100249"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20151739"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.10.012"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/186337\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T22:47:17Z","timestamp":1779230837000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/186337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,2]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,2]]},"published-print":{"date-parts":[[2025,1,2]]}},"alternative-id":["10.1172\/JCI186337"],"URL":"https:\/\/doi.org\/10.1172\/jci186337","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,2]]},"article-number":"e186337"}}