{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:16:15Z","timestamp":1792793775856,"version":"4.5.0"},"reference-count":20,"publisher":"American Society for Clinical Investigation","issue":"23","license":[{"start":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T00:00:00Z","timestamp":1733097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,2]]},"abstract":"<jats:p>\n                    The cyclic GMP-AMP synthase\/stimulator of interferon genes (cGAS\/STING) pathway is a critical driver of type I interferon (IFN-I) and antitumor CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell responses after radiotherapy (RT). In this issue of the\n                    <jats:italic>JCI<\/jats:italic>\n                    , two reports describe mechanisms that restrained STING signaling and abrogated antitumor immunity after RT. Wen, Wang, and colleagues discovered that IFN-I mediated the induction of YTHDF1, an RNA\n                    <jats:italic>\n                      N\n                      <jats:sup>6<\/jats:sup>\n                    <\/jats:italic>\n                    -methyladenosine\u2013binding protein, in DCs after RT promoted cathepsin-mediated STING degradation. Zhang, Deng, Wu, and colleagues discovered that hemeoxygenase 1 (HO-1) was induced and proteolytically cleaved after RT to suppress cGAS cytoplasmic export as well as STING oligomerization at the ER. Blocking the STING-suppressive functions of YTHDF1 and HO-1, respectively, improved antitumor T cell immunity and tumor control after RT. Together, these studies support the development of clinical avenues to sustain STING signaling during RT, a standard treatment for approximately 50% of malignancies.\n                  <\/jats:p>","DOI":"10.1172\/jci186547","type":"journal-article","created":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T14:00:32Z","timestamp":1733061632000},"source":"Crossref","is-referenced-by-count":10,"title":["Taking the STING out of radiotherapy: STING checkpoints mediate radiation resistance"],"prefix":"10.1172","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3957-1164","authenticated-orcid":true,"given":"Michael C.","family":"Brown","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin T.","family":"Low","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle L.","family":"Bowie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Ashley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2024,12,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2024.02.019"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.10.017"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.10.019"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101158"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-2820"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-017-0120-0"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2022.04.009"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.01.015"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36132-9"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1172\/JCI181612"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1172\/JCI181044"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-0916-x"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05354-0"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.11.061"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-00491-x"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01566-5"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0809242105"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-022-00490-y"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.11.022"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1172\/JCI163452"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/186547\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T22:59:13Z","timestamp":1779231553000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/186547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,2]]},"references-count":20,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2024,12,2]]},"published-print":{"date-parts":[[2024,12,2]]}},"alternative-id":["10.1172\/JCI186547"],"URL":"https:\/\/doi.org\/10.1172\/jci186547","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,2]]},"article-number":"e186547"}}