{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T19:54:50Z","timestamp":1772394890504,"version":"3.50.1"},"reference-count":90,"publisher":"American Society for Clinical Investigation","issue":"5","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":53,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH\/NCI","award":["R01CA178999"],"award-info":[{"award-number":["R01CA178999"]}]},{"name":"NIH\/NCI","award":["R01CA254403"],"award-info":[{"award-number":["R01CA254403"]}]},{"name":"NIH\/NCI","award":["R01CA254403-S1"],"award-info":[{"award-number":["R01CA254403-S1"]}]},{"name":"NIH\/NCI","award":["R01CA254403-S2"],"award-info":[{"award-number":["R01CA254403-S2"]}]},{"name":"NIH\/NIGMS","award":["5K12GM000680 IRACDA FIRST"],"award-info":[{"award-number":["5K12GM000680 IRACDA FIRST"]}]},{"name":"NIH\/NCI","award":["P30CA138292"],"award-info":[{"award-number":["P30CA138292"]}]},{"name":"NIH\/NCI","award":["R01CA301614"],"award-info":[{"award-number":["R01CA301614"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,2]]},"DOI":"10.1172\/jci186711","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T17:00:32Z","timestamp":1767891632000},"source":"Crossref","is-referenced-by-count":0,"title":["MRE11 deacetylation by SIRT2 promotes DNA binding to facilitate DNA end resection and ATM-dependent signaling"],"prefix":"10.1172","volume":"136","author":[{"given":"Fatmata","family":"Sesay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priya","family":"Kapoor-Vazirani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew T.","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark E.","family":"Essien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda J.","family":"Bastien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nho C.","family":"Luong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PamelaSara E.","family":"Head","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duc M.","family":"Duong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary S.","family":"Buchwald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingming","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas T.","family":"Seyfried","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"232","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2015.07.009"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.07.029"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-019-0152-0"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.09.019"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/nature08467"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.06.033"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3047"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2010.10.001"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(01)00381-1"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00335-X"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.110144297"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.08.017"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.10.010"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/nature10515"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1957"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80097-0"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.34.21447"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.11.003"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1126\/science.1091496"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1126\/science.1108297"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210872"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M706912200"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.190030497"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3546"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg541"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-4138"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06889-6"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.09.001"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2008.09.007"},{"issue":"1","key":"B30","first-page":"23","article-title":"Alterations of the double-strand break repair gene MRE11 in cancer","volume":"61","author":"Fukuda","year":"2001","journal-title":"Cancer Res"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207409"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1093\/embo-reports\/kvf044"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-019-0844-y"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgh257"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1995.1217"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.7150\/jca.31454"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djs355"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.02.037"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81547-0"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1212\/NXG.0000000000000295"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.4103\/jpn.JPN_152_19"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1002\/humu.23773"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi027"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh221"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1089\/gte.2008.0011"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201592934"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201592462"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M308705200"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1128\/JB.182.21.6036-6041.2000"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkf574"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/21.16.3851"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M106179200"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M309877200"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.10.1276"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.11.022"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03817-5"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.02025-07"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.4161\/cc.4.12.2250"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1279805"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-16-2787"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv754"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2009.07.006"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1306328110"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1038\/nature08197"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1100831"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210616"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2016.1184517"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2011.09.004"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1101\/gad.211342.112"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.772566"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.01.018"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.108921"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1111\/gtc.12842"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1301463110"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad549"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(03)00038-8"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.04.038"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg509"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2009.86"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth0410-248"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2011.09.010"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1038\/35007091"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1038\/35013089"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1038\/35013083"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2007.05.029"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007277"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1667\/RR15282.1"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2022.101313"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34578-x"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1021\/pr100666c"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/186711\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T19:01:34Z","timestamp":1772391694000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/186711"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,8]]},"references-count":90,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,12,23]]},"published-print":{"date-parts":[[2026,3,2]]}},"alternative-id":["10.1172\/JCI186711"],"URL":"https:\/\/doi.org\/10.1172\/jci186711","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,8]]},"article-number":"e186711"}}