{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:59:30Z","timestamp":1787018370420,"version":"build-2736575974"},"reference-count":20,"publisher":"American Society for Clinical Investigation","issue":"24","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,16]]},"abstract":"<jats:p>\n                    Following respiratory infection or injury, neutrophil hyperactivation can damage surrounding lung tissue by releasing harmful compounds. In this issue of the\n                    <jats:italic>JCI<\/jats:italic>\n                    , Moussavi-Harami and colleagues identified tyrosine phosphatase SHP1 as a key negative regulator of neutrophil activation in acute respiratory distress syndrome (ARDS). Neutrophil-specific\n                    <jats:italic>Shp1<\/jats:italic>\n                    disruption leads to hyperinflammation, pulmonary hemorrhage, and increased mortality in both sterile and pathogen-induced acute lung injury (ALI). Large intravascular neutrophil clusters and excessive PAD4-independent neutrophil extracellular traps (NETs) were identified as key features of lung injury. Mechanistically,\n                    <jats:italic>Shp1<\/jats:italic>\n                    deficiency resulted in uncontrolled SYK kinase activation, driving chaotic neutrophil hyperactivation and inflammation.\n                  <\/jats:p>","DOI":"10.1172\/jci187056","type":"journal-article","created":{"date-parts":[[2024,12,15]],"date-time":"2024-12-15T14:00:43Z","timestamp":1734271243000},"source":"Crossref","is-referenced-by-count":11,"title":["Balancing immune response: SHP1 controls neutrophil activation in inflamed lungs"],"prefix":"10.1172","volume":"134","author":[{"given":"Laxman","family":"Ghimire","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo R.","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.06.006"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.12.004"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathmechdis-051222-015009"},{"issue":"24","key":"B4","doi-asserted-by":"crossref","DOI":"10.1172\/JCI183161","article-title":"Loss of neutrophil Shp1 produces hemorrhagic and lethal acute lung injury","volume":"134","author":"Moussavi-Harami","year":"2024","journal-title":"J Clin Invest"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.2MR0317-105R"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00666.x"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.23.021704.115647"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-11-844530"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2009.07.011"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/nri2765"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00303-5"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a002352"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202303-0558WS"},{"issue":"23","key":"B14","first-page":"2526","article-title":"Acute respiratory distress syndrome: the Berlin definition","volume":"307","author":"Force","year":"2012","journal-title":"JAMA"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201609-1773CP"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.151.5.7735596"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00311.2013"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.15e14.x"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aal4045"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201439466"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/187056\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T22:45:19Z","timestamp":1779230719000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/187056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,16]]},"references-count":20,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2024,10,21]]},"published-print":{"date-parts":[[2024,12,16]]}},"alternative-id":["10.1172\/JCI187056"],"URL":"https:\/\/doi.org\/10.1172\/jci187056","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,16]]},"article-number":"e187056"}}