{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:13:45Z","timestamp":1790802825257,"version":"4.1.0"},"reference-count":27,"publisher":"American Society for Clinical Investigation","issue":"24","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,16]]},"abstract":"<jats:p>\n                    Despite the impressive clinical benefits and widespread adoption of sodium glucose cotransporter 2 inhibitors (SGLT2i) to treat all classes of heart failure, their cardiovascular mechanisms of action are poorly understood. Proposed mechanisms range broadly and include enhanced ketogenesis, where the mild ketosis associated with SGLT2i use is presumed to be beneficial. However, in this issue of the\n                    <jats:italic>JCI<\/jats:italic>\n                    , carefully conducted metabolic flux studies by Goedeke et al. comparing the effects of SGLT2i and exogenous ketones suggest differential effects. Thus, the mechanisms of action for SGLT2i are likely pleiotropic, and further work is needed to fully understand their beneficial effects.\n                  <\/jats:p>","DOI":"10.1172\/jci187097","type":"journal-article","created":{"date-parts":[[2024,12,15]],"date-time":"2024-12-15T14:00:43Z","timestamp":1734271243000},"source":"Crossref","is-referenced-by-count":8,"title":["Beyond ketosis: the search for the mechanism underlying SGLT2-inhibitor benefit continues"],"prefix":"10.1172","volume":"134","author":[{"given":"Justin H.","family":"Berger","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5411-3674","authenticated-orcid":true,"given":"Brian N.","family":"Finck","sequence":"additional","affiliation":[{"name":"Division of Nutritional Science and Obesity Medicine, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1911303"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2022190"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2107038"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2206286"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001063"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab368"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.065517"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abp9952"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2023.05.007"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2021.04.014"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2020.02.004"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.017355"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.017545"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.124079"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.120.007684"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc8861"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.036459"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.123.321872"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1172\/JCI176708"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2023.101334"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.124.324823"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.317933"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000001474"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.122.061688"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-017-4509-7"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaa323"},{"key":"B27","doi-asserted-by":"crossref","unstructured":"Forelli N, et al. SGLT2 inhibitors activate pantothenate kinase in the human heart [preprint]. https:\/\/doi.org\/10.1101\/2024.07.26.605401 Posted on bioRxiv July 27, 2024","DOI":"10.1101\/2024.07.26.605401"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/187097\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T22:45:00Z","timestamp":1779230700000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/187097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,16]]},"references-count":27,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2024,10,21]]},"published-print":{"date-parts":[[2024,12,16]]}},"alternative-id":["10.1172\/JCI187097"],"URL":"https:\/\/doi.org\/10.1172\/jci187097","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,16]]},"article-number":"e187097"}}