{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:11:24Z","timestamp":1788541884298,"version":"build-2803163510"},"reference-count":57,"publisher":"American Society for Clinical Investigation","issue":"16","license":[{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"vor","delay-in-days":59,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH","award":["R01-DK099110"],"award-info":[{"award-number":["R01-DK099110"]}]},{"name":"NIH","award":["R01-DK127274"],"award-info":[{"award-number":["R01-DK127274"]}]},{"name":"NIH","award":["R01-DK131537"],"award-info":[{"award-number":["R01-DK131537"]}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"crossref","award":["Career Development Award 855170"],"award-info":[{"award-number":["Career Development Award 855170"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"crossref","award":["P30-DK127984"],"award-info":[{"award-number":["P30-DK127984"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NIH","award":["1S10OD021684-0"],"award-info":[{"award-number":["1S10OD021684-0"]}]},{"name":"NIH","award":["P01-AG051459"],"award-info":[{"award-number":["P01-AG051459"]}]},{"name":"NIH","award":["R01-DK055758"],"award-info":[{"award-number":["R01-DK055758"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,15]]},"abstract":"<jats:p>\n                    Proinflammatory signaling in adipocytes is essential for healthy adipose expansion, remodeling, and tissue integrity. We investigated the effects of targeting inflammation in either adipocytes or mammary gland epithelial cells, in the context of mammary tumor development, by locally expressing the antiinflammatory adenoviral RID\u03b1\/\u03b2 protein complex in a cell type\u2013specific manner. Suppression of adipocyte inflammation (RID\n                    <jats:sup>ad<\/jats:sup>\n                    mice) in a mammary tumor model driven by MMTV-PyMT (PyMT-RID\n                    <jats:sup>ad<\/jats:sup>\n                    mice) led to an elevated number of tumor-associated macrophages and upregulation of immunoregulatory molecules in the mammary fat pad. This was accompanied by metabolic dysfunction and abnormal mammary gland development. Importantly, this phenotype correlated with accelerated mammary tumor onset, enhanced growth, and lung metastasis. Tumors in PyMT-RID\n                    <jats:sup>ad<\/jats:sup>\n                    mice exhibited upregulated CD36 expression, suggesting enhanced fatty acid uptake. Conversely, suppression of inflammation in mammary gland epithelial cells by RID\u03b1\/\u03b2 expression (RID\n                    <jats:sup>MMTV<\/jats:sup>\n                    mice) decelerated mammary tumor growth without affecting tumor onset or macrophage accumulation. These findings highlight the differential impact on tumor development exerted through the suppression of inflammatory signals in different cell types in the microenvironment. Our results underscore the role of the suppression of adipocyte inflammation leading to a tumor-friendly microenvironment, promoting mammary cancer progression. This study sheds light on the complex interplay between inflammation, specifically driven by the adipocyte, in breast cancer pathogenesis.\n                  <\/jats:p>","DOI":"10.1172\/jci187202","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T12:00:11Z","timestamp":1750161611000},"source":"Crossref","is-referenced-by-count":6,"title":["Inhibiting inflammation in adipocytes accelerates mammary tumor development in mice"],"prefix":"10.1172","volume":"135","author":[{"given":"Dae-Seok","family":"Kim","sequence":"first","affiliation":[{"name":"Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4439-0077","authenticated-orcid":true,"given":"Toshiharu","family":"Onodera","sequence":"additional","affiliation":[{"name":"Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA."},{"name":"Department of Adipose Management, Osaka University Graduate School of Medicine, Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2596-3167","authenticated-orcid":true,"given":"Jan-Bernd","family":"Funcke","sequence":"additional","affiliation":[{"name":"Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyounghee","family":"Min","sequence":"additional","affiliation":[{"name":"Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9382-8517","authenticated-orcid":true,"given":"Qingzhang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA."},{"name":"Barnstable Brown Diabetes and Obesity Center, University of Kentucky College of Medicine, Lexington, Kentucky, USA."},{"name":"Markey Cancer Center, University of Kentucky, Lexington, Kentucky, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Lin","sequence":"additional","affiliation":[{"name":"Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiuhwei","family":"Chen","sequence":"additional","affiliation":[{"name":"Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanmin","family":"Joung","sequence":"additional","affiliation":[{"name":"Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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