{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:54:21Z","timestamp":1792598061451,"version":"4.5.0"},"reference-count":64,"publisher":"American Society for Clinical Investigation","issue":"11","license":[{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["PO1 CA163227,T90 DE030859,R01GM147365"],"award-info":[{"award-number":["PO1 CA163227,T90 DE030859,R01GM147365"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["153081,173338,180554,186331"],"award-info":[{"award-number":["153081,173338,180554,186331"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Canadian Cancer Society","award":["707683"],"award-info":[{"award-number":["707683"]}]},{"name":"Joint Institute for Cancer Research, University of Michigan","award":["Joint Institute for Cancer Research Award"],"award-info":[{"award-number":["Joint Institute for Cancer Research Award"]}]},{"DOI":"10.13039\/100017453","name":"Institute for Prostate Cancer Research","doi-asserted-by":"crossref","award":["IPCR"],"award-info":[{"award-number":["IPCR"]}],"id":[{"id":"10.13039\/100017453","id-type":"DOI","asserted-by":"crossref"}]},{"name":"U.S. Department of Defense","award":["W81XWH-22-1-0833,HT94252410252,W81XWH2110539"],"award-info":[{"award-number":["W81XWH-22-1-0833,HT94252410252,W81XWH2110539"]}]},{"DOI":"10.13039\/100000892","name":"Prostate Cancer Foundation","doi-asserted-by":"crossref","award":["PCF Young Investigator Award"],"award-info":[{"award-number":["PCF Young Investigator Award"]}],"id":[{"id":"10.13039\/100000892","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Sheppard Family Foundation","award":["Sheppard Scholar Award"],"award-info":[{"award-number":["Sheppard Scholar Award"]}]},{"name":"Smith Family Fellowship","award":["Smith Family Scholar Award"],"award-info":[{"award-number":["Smith Family Scholar Award"]}]},{"DOI":"10.13039\/501100015803","name":"BC Cancer Foundation","doi-asserted-by":"crossref","award":["1PRRG012"],"award-info":[{"award-number":["1PRRG012"]}],"id":[{"id":"10.13039\/501100015803","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004376","name":"Terry Fox Research Institute","doi-asserted-by":"crossref","award":["1109"],"award-info":[{"award-number":["1109"]}],"id":[{"id":"10.13039\/501100004376","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Science Foundation","award":["DMS 2152776"],"award-info":[{"award-number":["DMS 2152776"]}]},{"name":"Silver Family Innovation Foundation","award":["Silver Family Innovation Foundation Award"],"award-info":[{"award-number":["Silver Family Innovation Foundation Award"]}]},{"name":"National Cancer Institute","award":["R01 CA251245,R01 CA282005,P50 CA186786,P30CA046592,1P50CA275741,R50 CA274336,P50CA97186,CA214955-01A1,R01 CA291986"],"award-info":[{"award-number":["R01 CA251245,R01 CA282005,P50 CA186786,P30CA046592,1P50CA275741,R50 CA274336,P50CA97186,CA214955-01A1,R01 CA291986"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,2]]},"abstract":"<jats:p>Lineage plasticity is recognized as a critical determinant of lethality and resistance to AR pathway inhibitors in prostate cancer. Lineage plasticity is a continuum, ranging from AR activity-low tumors, AR-null tumors that do not express a neuroendocrine prostate cancer (NEPC) program (i.e., double-negative prostate cancer [DNPC]), and AR-null NEPC tumors. Factors upregulated early in lineage plasticity are not well-characterized. The clarification of such factors is essential to identify tumors undergoing lineage plasticity or at risk of this occurring. Our integrative analysis of metastatic prostate cancer patient tumors, patient-derived xenografts, and cell models determined that PROX1 is upregulated early in the lineage plasticity continuum and progressively increases as tumors lose AR activity. We determined DNA methylation is a key regulator of PROX1 expression. PROX1 suppression in DNPC and NEPC reduces cell survival and impacts apoptosis and differentiation, demonstrating PROX1\u2019s functional importance. PROX1 is not directly targetable with standard drug development approaches. However, affinity immunopurification demonstrated histone deacetylases (HDACs) are among the top PROX1-interacting proteins; HDAC inhibition depletes PROX1 and recapitulates PROX1 suppression in DNPC and NEPC. Altogether, our results suggest PROX1 promotes the emergence of lineage plasticity, and HDAC inhibition is a promising approach to treat tumors across the lineage plasticity continuum.<\/jats:p>","DOI":"10.1172\/jci187490","type":"journal-article","created":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T14:00:41Z","timestamp":1748786441000},"source":"Crossref","is-referenced-by-count":17,"title":["PROX1 is an early driver of lineage plasticity in prostate cancer"],"prefix":"10.1172","volume":"135","author":[{"given":"Zhi","family":"Duan","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and"},{"name":"Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingchen","family":"Shi","sequence":"additional","affiliation":[{"name":"Vancouver Prostate Centre, Vancouver, British Columbia, Canada."},{"name":"Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada."},{"name":"BC Cancer Research Institute, BC Cancer, Vancouver, British Columbia, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9997-7430","authenticated-orcid":true,"given":"Anbarasu","family":"Kumaraswamy","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and"},{"name":"Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0303-2599","authenticated-orcid":true,"given":"Dong","family":"Lin","sequence":"additional","affiliation":[{"name":"Vancouver Prostate Centre, Vancouver, British Columbia, Canada."},{"name":"Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada."},{"name":"BC Cancer Research Institute, BC Cancer, Vancouver, British Columbia, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhruv","family":"Khokhani","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and"},{"name":"Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Wang","sequence":"additional","affiliation":[{"name":"Vancouver Prostate Centre, Vancouver, British Columbia, Canada."},{"name":"Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada."},{"name":"BC Cancer Research Institute, BC Cancer, Vancouver, British Columbia, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and"},{"name":"Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Flores","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and"},{"name":"Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Rodansky","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and"},{"name":"Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia A.","family":"Swaim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and"},{"name":"Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8100-9191","authenticated-orcid":true,"given":"William K.","family":"Storck","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and"},{"name":"Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah N.","family":"Beck","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and"},{"name":"Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhika A.","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3922-5683","authenticated-orcid":true,"given":"Erolcan","family":"Sayar","sequence":"additional","affiliation":[{"name":"Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian P.","family":"Hanratty","sequence":"additional","affiliation":[{"name":"Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Xue","sequence":"additional","affiliation":[{"name":"Vancouver Prostate Centre, Vancouver, British Columbia, Canada."},{"name":"Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada."},{"name":"BC Cancer Research Institute, BC Cancer, Vancouver, British Columbia, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Dong","sequence":"additional","affiliation":[{"name":"Vancouver Prostate Centre, Vancouver, British Columbia, Canada."},{"name":"Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada."},{"name":"BC Cancer Research Institute, BC Cancer, Vancouver, British Columbia, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe R.","family":"Maylin","sequence":"additional","affiliation":[{"name":"Vancouver Prostate Centre, Vancouver, British Columbia, Canada."},{"name":"Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada."},{"name":"BC Cancer Research Institute, BC Cancer, Vancouver, British Columbia, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rensheng","family":"Wan","sequence":"additional","affiliation":[{"name":"Helen Diller Family Comprehensive Cancer Center,"},{"name":"Department of Radiation Oncology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Quigley","sequence":"additional","affiliation":[{"name":"Helen Diller Family Comprehensive Cancer Center,"},{"name":"Department of Epidemiology & Biostatistics, and"},{"name":"Department of Urology, UCSF, San Francisco, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Sj\u00f6str\u00f6m","sequence":"additional","affiliation":[{"name":"Helen Diller Family Comprehensive Cancer Center,"},{"name":"Department of Radiation Oncology,"},{"name":"Division of Oncology, Department of Clinical Sciences, Lund, Faculty of Medicine, Lund University, Lund, Sweden."},{"name":"Department of Haematology, Oncology and Radiation Physics, Sk\u00e5ne University Hospital, Lund, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2575-1770","authenticated-orcid":true,"given":"Ya-Mei","family":"Hu","sequence":"additional","affiliation":[{"name":"Knight Cancer Institute and"},{"name":"Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faming","family":"Zhao","sequence":"additional","affiliation":[{"name":"Knight Cancer Institute and"},{"name":"Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3364-8324","authenticated-orcid":true,"given":"Zheng","family":"Xia","sequence":"additional","affiliation":[{"name":"Knight Cancer Institute and"},{"name":"Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, LSU Health Shreveport, Shreveport, Louisiana, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuping","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, LSU Health Shreveport, Shreveport, Louisiana, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix Y.","family":"Feng","sequence":"additional","affiliation":[{"name":"Helen Diller Family Comprehensive Cancer Center,"},{"name":"Department of Radiation Oncology,"},{"name":"Department of Urology, UCSF, San Francisco, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Helen Diller Family Comprehensive Cancer Center,"},{"name":"Department of Epidemiology & Biostatistics, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Helen Diller Family Comprehensive Cancer Center,"},{"name":"Division of Hematology and Oncology, Department of Medicine, UCSF, San Francisco, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J.","family":"Small","sequence":"additional","affiliation":[{"name":"Helen Diller Family Comprehensive Cancer Center,"},{"name":"Division of Hematology and Oncology, Department of Medicine, UCSF, San Francisco, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4670-3898","authenticated-orcid":true,"given":"Visweswaran","family":"Ravikumar","sequence":"additional","affiliation":[{"name":"Department of Computational Medicine & Bioinformatics,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9613-426X","authenticated-orcid":true,"given":"Arvind","family":"Rao","sequence":"additional","affiliation":[{"name":"Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, USA."},{"name":"Department of Computational Medicine & Bioinformatics,"},{"name":"Department of Biomedical Engineering,"},{"name":"Department of Radiation Oncology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7843-738X","authenticated-orcid":true,"given":"Karan","family":"Bedi","sequence":"additional","affiliation":[{"name":"Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, USA."},{"name":"Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John K.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine and the Institute for Urologic Oncology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colm","family":"Morrissey","sequence":"additional","affiliation":[{"name":"Department of Urology, University of Washington, Seattle, Washington, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilsa","family":"Coleman","sequence":"additional","affiliation":[{"name":"Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter S.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA."},{"name":"Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9244-3807","authenticated-orcid":true,"given":"Eva","family":"Corey","sequence":"additional","affiliation":[{"name":"Department of Urology, University of Washington, Seattle, Washington, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8254-5404","authenticated-orcid":true,"given":"Aaron M.","family":"Udager","sequence":"additional","affiliation":[{"name":"Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, USA."},{"name":"Department of Pathology,"},{"name":"Michigan Center for Translational Pathology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan J.","family":"Rebernick","sequence":"additional","affiliation":[{"name":"Department of Computational Medicine & Bioinformatics,"},{"name":"Department of Pathology,"},{"name":"Michigan Center for Translational Pathology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin P.","family":"Cieslik","sequence":"additional","affiliation":[{"name":"Department of Computational Medicine & Bioinformatics,"},{"name":"Department of Pathology,"},{"name":"Michigan Center for Translational Pathology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arul M.","family":"Chinnaiyan","sequence":"additional","affiliation":[{"name":"Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, USA."},{"name":"Department of Pathology,"},{"name":"Michigan Center for Translational Pathology, and"},{"name":"Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1462-8494","authenticated-orcid":true,"given":"Joel A.","family":"Yates","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and"},{"name":"Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Haffner","sequence":"additional","affiliation":[{"name":"Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA."},{"name":"Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA."},{"name":"Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9749-8591","authenticated-orcid":true,"given":"Yuzhuo","family":"Wang","sequence":"additional","affiliation":[{"name":"Vancouver Prostate Centre, Vancouver, British Columbia, Canada."},{"name":"Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada."},{"name":"BC Cancer Research Institute, BC Cancer, Vancouver, British Columbia, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1278-0166","authenticated-orcid":true,"given":"Joshi J.","family":"Alumkal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and"},{"name":"Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, USA."},{"name":"Michigan Center for Translational Pathology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2025,6,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21871"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2024.0591"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.09.003"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.77.6880"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-1423"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32701-6"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4045"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-23-0593"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1172\/JCI128212"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1126\/science.abn0478"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-022-00431-9"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.978"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.3.443"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4773(93)90012-M"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21422"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1013456108"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000565"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90463-9"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.102953"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018454"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.217068"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.06.039"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1902651116"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-2921-T"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.07.012"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-020-0648-8"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-22-1123"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/nrg.2017.33"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205699"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22139-7"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/s41698-024-00667-x"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-20-4968"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80299-3"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1158\/2767-9764.CRC-23-0250"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.21.6150"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-024-00729-w"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-0055"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.07.024"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah4307"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah4199"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-08150-0"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23780-y"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-23-0539"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-024-01025-z"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-51156-5"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.185952"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-24-1388"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26042-z"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-024-00838-6"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-023-01145-3"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-1589"},{"issue":"17","key":"B52","first-page":"4916","article-title":"FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases","volume":"62","author":"Furumai","year":"2002","journal-title":"Cancer Res"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.490706"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.03.001"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-15-1263"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1126\/science.abe1505"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1002\/pros.23313"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17204-5"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.27"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.167440"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2017.166"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2089"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.146827"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-21-4289"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/187490\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T22:55:38Z","timestamp":1779231338000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/187490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,2]]},"references-count":64,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,6,2]]},"published-print":{"date-parts":[[2025,6,2]]}},"alternative-id":["10.1172\/JCI187490"],"URL":"https:\/\/doi.org\/10.1172\/jci187490","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,2]]},"article-number":"e187490"}}