{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:07:04Z","timestamp":1779232024856,"version":"3.51.4"},"reference-count":20,"publisher":"American Society for Clinical Investigation","issue":"2","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,16]]},"abstract":"<jats:p>\n                    Superantigen-induced (Sag-induced) autoimmunity has been proposed as a mechanism for many human disorders, without a clear understanding of the potential triggers. In this issue of the\n                    <jats:italic>JCI<\/jats:italic>\n                    , McCarthy and colleagues used the SKG mouse model of rheumatoid arthritis to characterize the role of Sag activity in inflammatory arthritis by profiling arthritogenic naive CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells. Within the diseased joints, they found a marked enrichment of T cell receptor\u2013variable \u03b2 (TCR-V\u03b2) subsets that were reactive to the endogenously encoded mouse mammary tumor virus (MMTV) Sag. Arthritis was improved using reverse transcriptase inhibitors. Moreover, depletion of MMTV Sag-activated TCR-V\u03b2 subsets affected the ability of transferred activated CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells to induce disease in mice with severe combined immunodeficiency (SCID). Further virological studies should determine whether endogenous or exogenous MMTV is necessary or sufficient to trigger inflammatory arthritis in the SKG model.\n                  <\/jats:p>","DOI":"10.1172\/jci187567","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T14:00:44Z","timestamp":1736949644000},"source":"Crossref","is-referenced-by-count":0,"title":["A new twist on superantigen-activated autoimmune disease"],"prefix":"10.1172","volume":"135","author":[{"given":"Andrew L.","family":"Mason","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doaa","family":"Waly","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed S.","family":"Osman","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Center of Excellence for Intestinal and Immunology Research, University of Alberta, Edmonton, Alberta, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"232","published-online":{"date-parts":[[2025,1,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200403000-00006"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02119"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12841"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1904271116"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1172\/JCI174647"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.2741\/2172"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.158.10.4642"},{"issue":"9","key":"B8","first-page":"1821","article-title":"Expression of human endogenous retrovirus HERV-K18 superantigen is elevated in juvenile rheumatoid arthritis","volume":"32","author":"Sicat","year":"2005","journal-title":"J Rheumatol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2010.02257.x"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/nature11599"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1097\/00054725-200211000-00003"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-023-01483-4"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-023-01483-4"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1126\/science.1210718"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12699"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.01.037"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1007187"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3390\/v14091941"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1433063100"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3390\/v14050886"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/187567\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T22:47:42Z","timestamp":1779230862000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/187567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,16]]},"references-count":20,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,1,16]]},"published-print":{"date-parts":[[2025,1,16]]}},"alternative-id":["10.1172\/JCI187567"],"URL":"https:\/\/doi.org\/10.1172\/jci187567","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,16]]},"article-number":"e187567"}}