{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T23:05:47Z","timestamp":1787871947434,"version":"build-2784847793"},"reference-count":79,"publisher":"American Society for Clinical Investigation","issue":"13","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":63,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["5R01AI162929"],"award-info":[{"award-number":["5R01AI162929"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["R01AI100873"],"award-info":[{"award-number":["R01AI100873"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100023363","name":"Praespero Foundation","doi-asserted-by":"crossref","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100023363","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"crossref","award":["T32NS115664"],"award-info":[{"award-number":["T32NS115664"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"crossref","award":["R35NS116835"],"award-info":[{"award-number":["R35NS116835"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:p>\n                    Stem-like T cells selectively contribute to autoimmunity, but the activities that promote their pathogenicity are incompletely understood. Here, we identify the transcription coregulator OCA-B as a driver of the pathogenic maturation of stem-like CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells to promote autoimmune demyelination. Using 2 human multiple sclerosis (MS) datasets, we show that\n                    <jats:italic>POU2AF1<\/jats:italic>\n                    , the gene encoding OCA-B, is elevated in CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells from patients with MS. We show that T cell\u2013intrinsic OCA-B loss protects mice from experimental autoimmune encephalomyelitis (EAE) while preserving responses to viral CNS infection. In EAE models driven by antigen re-encounter, OCA-B deletion nearly eliminates CNS infiltration, proinflammatory cytokine production, and clinical disease. OCA-B\u2013expressing CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells of mice primed with autoantigen express an encephalitogenic gene program and preferentially confer disease. In a relapsing-remitting EAE model, OCA-B loss protects mice specifically at relapse. During remission, OCA-B promotes the expression of\n                    <jats:italic>Tcf7<\/jats:italic>\n                    ,\n                    <jats:italic>Slamf6<\/jats:italic>\n                    , and\n                    <jats:italic>Sell<\/jats:italic>\n                    in proliferating CNS T cell populations. At relapse time points, OCA-B loss results in both the accumulation of an immunomodulatory CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell population expressing\n                    <jats:italic>Ccr9<\/jats:italic>\n                    and\n                    <jats:italic>Bach2<\/jats:italic>\n                    , and loss of proinflammatory gene expression from Th17 cells. These results identify OCA-B as a driver of pathogenic CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells.\n                  <\/jats:p>","DOI":"10.1172\/jci187862","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T12:00:15Z","timestamp":1745928015000},"source":"Crossref","is-referenced-by-count":5,"title":["OCA-B promotes pathogenic maturation of stem-like CD4+ T cells and autoimmune demyelination"],"prefix":"10.1172","volume":"135","author":[{"given":"Erik P.","family":"Hughes","sequence":"first","affiliation":[{"name":"Department of Pathology,"},{"name":"Huntsman Cancer Institute, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber R.","family":"Syage","sequence":"additional","affiliation":[{"name":"Department of Pathology,"},{"name":"Huntsman Cancer Institute, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elnaz","family":"Mirzaei Mehrabad","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute, and"},{"name":"Department of Oncological Sciences, University of Utah School of Medicine, Salt Lake City, Utah, USA."},{"name":"School of Computing, University of Utah, Salt Lake City, Utah, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Lane","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Behavior, School of Biological Sciences, University of California, Irvine, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin T.","family":"Spike","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute, and"},{"name":"Department of Oncological Sciences, University of Utah School of Medicine, Salt Lake City, Utah, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1354-8385","authenticated-orcid":true,"given":"Dean","family":"Tantin","sequence":"additional","affiliation":[{"name":"Department of Pathology,"},{"name":"Huntsman Cancer Institute, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458520970841"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10251"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1086\/444547"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3109\/08916939608995329"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041257"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp289"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2008.08.030"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6056"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.160.3.1532"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1006\/cimm.2001.1842"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.3.1641"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1528"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08482-w"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2011.02.008"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.080142"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1126\/science.1222794"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl395"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.11.1281"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/nature13835"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20150363"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1523-3"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007687"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.add5750"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1242\/dev.047027"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2016.04.006"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2003.08.002"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3154"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/383542a0"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2006.06.003"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2012.08.010"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2309153121"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20200533"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2010.10.043"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.5.2991"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.042684699"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00492"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/89750"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2012.08.269"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701484"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/nature11981"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.05.057"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.792"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2024.11.016"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adp1720"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20141015"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080159"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201343723"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.11.018"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0414-6"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2024.01.007"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04842-7"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/383538a0"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.17.5066"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1038\/ni1008-1091"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5323.221"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2024.01.004"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1111\/imr.13356"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04248-x"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-024-01860-7"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adh0380"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.11.045"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.154.10.5536"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-023-01553-7"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(92)90016-E"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1007\/s001090050092"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102186"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2015_378"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20161046"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054326"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz012"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-024-01901-1"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020010175"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00543"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.3.1415-1424.2000"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.06.009"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0157620"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2017.09.001"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.03.025"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0699-z"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/187862\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T17:16:45Z","timestamp":1779211005000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/187862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,29]]},"references-count":79,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2025,5,13]]},"published-print":{"date-parts":[[2025,7,1]]}},"alternative-id":["10.1172\/JCI187862"],"URL":"https:\/\/doi.org\/10.1172\/jci187862","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.11.29.569210","asserted-by":"object"}]},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,29]]},"article-number":"e187862"}}