{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:28:26Z","timestamp":1792225706731,"version":"4.4.0"},"reference-count":108,"publisher":"American Society for Clinical Investigation","issue":"1","license":[{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"vor","delay-in-days":71,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R35 CA197695,P30 CA021765,R01CA27611701,R01AI136941,T32GM145470"],"award-info":[{"award-number":["R35 CA197695,P30 CA021765,R01CA27611701,R01AI136941,T32GM145470"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100012524","name":"American Lebanese Syrian Associated Charities","doi-asserted-by":"crossref","award":["None"],"award-info":[{"award-number":["None"]}],"id":[{"id":"10.13039\/100012524","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100003287","name":"Rally Foundation","doi-asserted-by":"crossref","award":["None"],"award-info":[{"award-number":["None"]}],"id":[{"id":"10.13039\/100003287","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100017065","name":"Rogel Cancer Center, University of Michigan","doi-asserted-by":"crossref","award":["None"],"award-info":[{"award-number":["None"]}],"id":[{"id":"10.13039\/100017065","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006801","name":"Horace H. Rackham School of Graduate Studies, University of Michigan","doi-asserted-by":"crossref","award":["None"],"award-info":[{"award-number":["None"]}],"id":[{"id":"10.13039\/100006801","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,2]]},"abstract":"<jats:p>\n                    There is an urgent need to find targeted agents for T cell acute lymphoblastic leukemia (T-ALL).\n                    <jats:italic>NOTCH1<\/jats:italic>\n                    is the most frequently mutated oncogene in T-ALL, but clinical trials showed that pan-Notch inhibitors caused dose-limiting toxicities. Thus, we shifted our focus to ETS1, which is one of the transcription factors that most frequently co-bind Notch-occupied regulatory elements in the T-ALL context. To identify the most essential enhancers, we performed a genome-wide CRISPRi screen of the strongest ETS1-dependent regulatory elements. The top-ranked element is located in an intron of\n                    <jats:italic>AHI1<\/jats:italic>\n                    that interacts with the MYB promoter and is amplified with\n                    <jats:italic>MYB<\/jats:italic>\n                    in approximately 8.5% of patients with T-ALL. Using mouse models, we showed that this enhancer promoted self-renewal of hematopoietic stem cells and T cell leukemogenesis, maintained early T cell precursors, and restrained myeloid expansion with aging. We named this enhancer the hematopoietic stem cell MYB enhancer (H-Me). The H-Me showed limited activity and function in committed T cell progenitors but was accessed during leukemogenesis. In one T-ALL context, ETS1 bound the ETS motif in the H-Me to recruit cBAF to promote chromatin accessibility and activation. ETS1 or cBAF degraders impaired H-Me function. Thus, we identified a targetable stem cell element that was co-opted for T cell transformation.\n                  <\/jats:p>","DOI":"10.1172\/jci187998","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:00:26Z","timestamp":1761235226000},"source":"Crossref","is-referenced-by-count":1,"title":["The hematopoietic stem cell MYB enhancer is essential for and recurrently amplified during T cell leukemogenesis"],"prefix":"10.1172","volume":"136","author":[{"given":"Carea","family":"Mullin","sequence":"first","affiliation":[{"name":"Division of Hematology-Oncology, Department of Internal Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karena","family":"Lin","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Biology Program, University of Michigan School of Medicine, Ann Arbor, Michigan, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Choe","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Department of Internal Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cher","family":"Sha","sequence":"additional","affiliation":[{"name":"Immunology and Microbiology Program, Baylor College of Medicine, Houston, Texas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeel","family":"Shukla","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Department of Internal Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koral","family":"Campbell","sequence":"additional","affiliation":[{"name":"Molecular and Cellular Pathology Program, University of Michigan, Ann Arbor, Michigan, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna C.","family":"McCarter","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Stanford, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Department of Internal Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jannaldo","family":"Nieves-Salva","sequence":"additional","affiliation":[{"name":"Immunology Program, University of Michigan School of Medicine, Ann Arbor, Michigan, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Khan","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Department of Internal Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa M.","family":"Keeley","sequence":"additional","affiliation":[{"name":"Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Liang","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Department of Internal Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Department of Internal Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley F.","family":"Melnick","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Biology Program, University of Michigan School of Medicine, Ann Arbor, Michigan, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pearl","family":"Evans","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Department of Internal Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7589-1026","authenticated-orcid":true,"given":"Alexander C.","family":"Monovich","sequence":"additional","affiliation":[{"name":"Molecular and Cellular Pathology Program, University of Michigan, Ann Arbor, Michigan, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwin","family":"Iyer","sequence":"additional","affiliation":[{"name":"Regeneron Pharmaceuticals, Tarrytown, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan","family":"Kodgule","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, WashU Medicine, St. Louis, Missouri, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamei","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"da Veiga Leprevost","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly R.","family":"Barnett","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Pharmaceutical Sciences, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6128-9985","authenticated-orcid":true,"given":"Petri","family":"P\u00f6l\u00f6nen","sequence":"additional","affiliation":[{"name":"Department of Pathology, St. Jude Children\u2019s Research Hospital, Memphis, Tennessee, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2539-5953","authenticated-orcid":true,"given":"Rami","family":"Khoriaty","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Department of Internal Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Savic","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Pharmaceutical Sciences, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T.","family":"Teachey","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1871-1850","authenticated-orcid":true,"given":"Charles G.","family":"Mullighan","sequence":"additional","affiliation":[{"name":"Department of Pathology, St. Jude Children\u2019s Research Hospital, Memphis, Tennessee, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Cieslik","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA."},{"name":"Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2806-7819","authenticated-orcid":true,"given":"Alexey I.","family":"Nesvizhskii","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA."},{"name":"Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda C.","family":"Samuelson","sequence":"additional","affiliation":[{"name":"Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4330-1722","authenticated-orcid":true,"given":"Morgan","family":"Jones","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Department of Internal Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Department of Internal Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8174-3962","authenticated-orcid":true,"given":"Russell J.H.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark Y.","family":"Chiang","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Department of Internal Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"key":"B1"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1102160"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-89512-3_18"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2006.24.18_suppl.6585"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.1540"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.8282"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/nature03659"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2015.03.012"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1242\/dev.070763"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.10.007"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.08.022"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.482"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.4161\/cc.11.2.18995"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2017.12.008"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aam6846"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2005892"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1242\/dev.094599"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aah4679"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.04.020"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023020144"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1158\/2643-3230.BCD-20-0026"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-19-0471"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021012077"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-03-775536"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2018.04.008"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2010.106"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.79.081507.103945"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-012-1243-7"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1109023108"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1315023111"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(02)01156-3"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11955-7"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0538-0"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3665"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1407079111"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.09.001"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-08-447839"},{"issue":"17","key":"B38","first-page":"5329","article-title":"The cardiac homeobox gene NKX2-5 is deregulated by juxtaposition with BCL11B in pediatric T-ALL cell lines via a novel t(5;14) (q35.1;q32.2)","volume":"63","author":"Nagel","year":"2003","journal-title":"Cancer Res"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-2615"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07807-0"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1002\/hem3.51"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.10.073"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1126\/science.7660125"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.03.005"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2013.05.014"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2015.05.003"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1002\/stem.761"},{"issue":"22","key":"B48","first-page":"5168","article-title":"c-Myb down-regulation is associated with human colon cell differentiation, apoptosis, and decreased Bcl-2 expression","volume":"58","author":"Thompson","year":"1998","journal-title":"Cancer Res"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1002\/path.2113"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2014.06.006"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(03)00081-2"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.20.7505-7515.2000"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.5.2283"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.2.655-664.2003"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/30756"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085883"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-12-064683"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20071637"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/ng2025"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3909"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1038\/nature05690"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1126\/science.1259037"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.06.007"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2439"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1101\/2023.11.06.23298028"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404243"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20122516"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2022.281583"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1126\/science.2255914"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/17.10.871"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.3390\/ncrna5010004"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiolchem.2015.02.012"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw804"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.01.006"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.05.049"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.1.91-103.2000"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-019-0294-6"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04246-z"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023020857"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-09-742148"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2018874503"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2023.283450"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00316"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0405338101"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00227-8"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-300343"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-03-416503"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1897910"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-24-1090"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1158\/2643-3230.BCD-20-0201"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-023-01993-y"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0907623106"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022019138"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90099-K"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-024-02331-6"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-020-0965-y"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1126\/science.abn2253"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-023-01626-1"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-08430-9"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07510-0"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.3390\/epigenomes8010007"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-017-1220-4"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1217812110"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1158\/2643-3230.BCD-21-0224"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0747-9"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4256"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-020-0912-y"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15283-z"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/187998\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T17:05:46Z","timestamp":1779210346000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/187998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,23]]},"references-count":108,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,2]]},"published-print":{"date-parts":[[2026,1,2]]}},"alternative-id":["10.1172\/JCI187998"],"URL":"https:\/\/doi.org\/10.1172\/jci187998","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,23]]},"article-number":"e187998"}}