{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:25:08Z","timestamp":1790461508415,"version":"4.1.0"},"reference-count":26,"publisher":"American Society for Clinical Investigation","issue":"2","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,16]]},"abstract":"<jats:p>\n                    How are autoreactive T cells induced and regulated in patients with autoimmune disease? This question lies at the core of understanding autoimmune disease pathologies, yet it has remained elusive due to host variability and the complexity of the immune system. In this issue of the JCI, Kramer and colleagues used autoimmune hepatitis (AIH) as a model to explore the maintenance of autoreactive CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells specific to O-phosphoseryl-tRNA:selenocysteine tRNA synthase (SepSecS). The findings provide insight into the interaction between T cells and B cells in AIH pathogenesis that may reflect a shared mechanism among other autoimmune diseases.\n                  <\/jats:p>","DOI":"10.1172\/jci188538","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T14:00:44Z","timestamp":1736949644000},"source":"Crossref","is-referenced-by-count":3,"title":["Elucidating the role of autoreactive T cells and B cells in autoimmune hepatitis"],"prefix":"10.1172","volume":"135","author":[{"given":"Yoshiaki","family":"Yasumizu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4664-535X","authenticated-orcid":true,"given":"David A.","family":"Hafler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2025,1,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102534"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-021-00768-8"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1172\/JCI183776"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0244-2"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900124"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa8038"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0540-1"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06916-6"},{"key":"B9","article-title":"Endogenous self-peptides guard immune privilege of the central nervous system","author":"Kim","journal-title":"Nature"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42541-7"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00319"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.66984"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12859"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.08.012"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00652-6"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27991"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-023-00897-3"},{"key":"B18","doi-asserted-by":"crossref","unstructured":"Wei J, et al. Systems analysis of immune changes after B-cell depletion in autoimmune multiple sclerosis [preprint]. https:\/\/doi.org\/10.1101\/2024.02.07.576204 Posted on bioRxiv February 9, 2024","DOI":"10.1101\/2024.02.07.576204"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.08.011"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.09.054"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.750753"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.2147\/CEG.S101440"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32417"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-020-0505-4"},{"key":"B25","doi-asserted-by":"crossref","unstructured":"Wu K, et al. TCR-BERT: learning the grammar of T-cell receptors for flexible antigen-xbinding analyses [preprint]. https:\/\/doi.org\/10.1101\/2021.11.18.469186 Posted on bioRxiv November 20, 2021","DOI":"10.1101\/2021.11.18.469186"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.11.018"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/188538\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T22:47:54Z","timestamp":1779230874000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/188538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,16]]},"references-count":26,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,1,16]]},"published-print":{"date-parts":[[2025,1,16]]}},"alternative-id":["10.1172\/JCI188538"],"URL":"https:\/\/doi.org\/10.1172\/jci188538","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,16]]},"article-number":"e188538"}}