{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T19:54:55Z","timestamp":1772394895547,"version":"3.50.1"},"reference-count":77,"publisher":"American Society for Clinical Investigation","issue":"5","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82103039"],"award-info":[{"award-number":["82103039"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Program of Shanghai Academic\/Technology Research Leader","award":["20XD1421100"],"award-info":[{"award-number":["20XD1421100"]}]},{"DOI":"10.13039\/100017633","name":"Shanghai Anti-Cancer Association","doi-asserted-by":"crossref","award":["SACA-AX202314"],"award-info":[{"award-number":["SACA-AX202314"]}],"id":[{"id":"10.13039\/100017633","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82473339"],"award-info":[{"award-number":["82473339"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82503865"],"award-info":[{"award-number":["82503865"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100017633","name":"Shanghai Anti-Cancer Association","doi-asserted-by":"crossref","award":["SACA-CY24A02"],"award-info":[{"award-number":["SACA-CY24A02"]}],"id":[{"id":"10.13039\/100017633","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Foundation of the Shanghai Municipal Education Commission","award":["No. 24RGZNA03"],"award-info":[{"award-number":["No. 24RGZNA03"]}]},{"name":"National Natural Science Foundation of Shanghai","award":["25ZR1402088"],"award-info":[{"award-number":["25ZR1402088"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,2]]},"DOI":"10.1172\/jci188989","type":"journal-article","created":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T19:00:56Z","timestamp":1772391656000},"source":"Crossref","is-referenced-by-count":0,"title":["Comprehensive genomic profiling of triple-negative breast cancer metastases identifies role of PKD1 in immunotherapy resistance"],"prefix":"10.1172","volume":"136","author":[{"given":"Xiu-Zhi","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Fan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Han","family":"Ying","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Yi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Hong","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun-Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Ming","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Zhou","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong-Hua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"232","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1001389"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2016.66"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2011.07.008"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.20892\/j.issn.2095-3941.2024.0009"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2014.0008"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)70064-1"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djab004"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2019.02.001"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1172\/JCI45014"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2024.02.002"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706450"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2028485"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2022.09.159"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.00368"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.64.0334"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.37.2482"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2014.08.014"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1172\/JCI96149"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1056-z"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1126\/science.aai8515"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-15-0369"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-021-00240-6"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.12.004"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-022-00491-x"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1172\/JCI130323"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.07.005"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-22-0764"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.62.2126"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2018.08.008"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-20-1647"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1689-y"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19342-3"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.01.003"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.01.010"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.06.056"},{"issue":"11","key":"B36","first-page":"3081","article-title":"Epidermal growth factor receptor vIII enhances tumorigenicity in human breast cancer","volume":"60","author":"Tang","year":"2000","journal-title":"Cancer Res"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-025-02045-2"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-025-04487-z"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0750-6"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-3524"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/nature07758"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1126\/science.1258096"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01165-x"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-310514"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2014.12.001"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-0428-5"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf2784"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1814213"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.4224"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1809615"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/nature10933"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-13-0286"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0507-7"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/nature08989"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/nature08489"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-023-00909-w"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2021.05.009"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2017.07.002"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2409932"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2112651"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1910549"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-018-0108-1"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0047-y"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2010.168"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-022-01341-0"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-0375-9"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-023-00795-2"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-21-4313"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(23)00579-X"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3312"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1038\/nature14136"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-3514"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-021-01930-w"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-019-0400-z"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-2341"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.630432"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/188989\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T19:01:50Z","timestamp":1772391710000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/188989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,2]]},"references-count":77,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,12,23]]},"published-print":{"date-parts":[[2026,3,2]]}},"alternative-id":["10.1172\/JCI188989"],"URL":"https:\/\/doi.org\/10.1172\/jci188989","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,2]]},"article-number":"e188989"}}