{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T07:12:17Z","timestamp":1781075537178,"version":"3.54.1"},"reference-count":20,"publisher":"American Society for Clinical Investigation","issue":"4","license":[{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,17]]},"abstract":"<jats:p>\n                    Chronic pain is a debilitating condition that affects up to 1.5 billion people globally. Advancing pain management depends on a thorough understanding of the types of pain experienced by patients and the underlying mechanisms driving it. N-type calcium channels play a crucial role as therapeutic targets for managing chronic pain. In this issue of the\n                    <jats:italic>JCI<\/jats:italic>\n                    , Tang et al. introduce C2230, an N-type calcium channel blocker that inhibited Ca\n                    <jats:sub>V<\/jats:sub>\n                    2.2 channels during high frequency stimulation with little effect on other ion channels in the pain pathway across multiple models. C2230 offers a promising analgesic for use in therapeutic intervention.\n                  <\/jats:p>","DOI":"10.1172\/jci189308","type":"journal-article","created":{"date-parts":[[2025,2,16]],"date-time":"2025-02-16T14:00:53Z","timestamp":1739714453000},"source":"Crossref","is-referenced-by-count":4,"title":["The N-type calcium channel rises from the ashes"],"prefix":"10.1172","volume":"135","author":[{"given":"Maria A.","family":"Gandini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald W.","family":"Zamponi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2025,2,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.114.009654"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0356-09.2009"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1403731111"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-013-0107-5"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.1.63"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2009.09.008"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2010.01.008"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1124\/mol.111.075226"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.110.166363"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13789"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1177\/1744806919858801"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2209870"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13906"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1172\/JCI177429"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0195-21.2021"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0311-24.2024"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22101693"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1111\/bph.16309"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-015-1791-2"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12001"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/189308\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T19:21:08Z","timestamp":1779218468000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/189308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,17]]},"references-count":20,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,12,31]]},"published-print":{"date-parts":[[2025,2,17]]}},"alternative-id":["10.1172\/JCI189308"],"URL":"https:\/\/doi.org\/10.1172\/jci189308","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,17]]},"article-number":"e189308"}}