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We investigated the influence of SIV infection in macaques (SIVmac) on the risk of comorbidities and aging in young and old rhesus macaques (RMs) by assessing pathogenesis markers, DNA methylation\u2013based epigenetic age (EA), and EA acceleration (EAA) in blood and tissues. Initially, upon SIV infection, the young RMs showed greater resilience to CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell depletion, better control of T cell activation, hypercoagulation, and excessive inflammation, yet this resilience was progressively lost in the advanced stages of infection. During the late stages of infection, the young RMs, but not the aged ones, showed an increase in EA in PBMCs; also, EAA in the cerebellum and heart of young RMs was higher compared with old RMs. SIV infection was more pathogenic in aged animals in early stages, leading to a more rapid disease progression; however, accelerated aging mostly affected young animals, so that the levels of multiple key pathogenesis markers in the young RMs converged toward those specific to aged ones in the late stages of infection. We conclude that SIV infection\u2013driven age acceleration is tissue specific, and that host age influences the susceptibility of different tissues to enhanced aging.\n                  <\/jats:p>","DOI":"10.1172\/jci189574","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T18:00:41Z","timestamp":1752516041000},"source":"Crossref","is-referenced-by-count":2,"title":["Pathogenic SIV infection is associated with acceleration of epigenetic age in rhesus macaques"],"prefix":"10.1172","volume":"135","author":[{"given":"Anna J.","family":"Jasinska","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine and"},{"name":"Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, 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