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Here, we define the pDC activation trajectory during\n                    <jats:italic>A<\/jats:italic>\n                    .\n                    <jats:italic>fumigatus<\/jats:italic>\n                    infection and the molecular events that underlie the protective pDC\u2013neutrophil crosstalk. Fungus-induced pDC activation began after bone marrow egress and resulted in pDC-dependent regulation of lung type I and type III IFN levels. These pDC-derived products acted on type I and type III IFN receptor\u2013expressing neutrophils and controlled neutrophil fungicidal activity and ROS production via STAT1 signaling in a cell-intrinsic manner. Mechanistically, neutrophil STAT1 signaling regulated transcription and expression of\n                    <jats:italic>Cybb<\/jats:italic>\n                    , which encodes one of 5 NADPH oxidase subunits. 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