{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T20:06:41Z","timestamp":1779221201655,"version":"3.51.4"},"reference-count":27,"publisher":"American Society for Clinical Investigation","issue":"8","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,15]]},"abstract":"<jats:p>\n                    Vaccine hesitancy is often fueled by fears of side effects; however, most reactions result from innate immune activation and cytokine production, which are required for lasting immunity. For effective vaccines against HIV, innate activation is essential for differentiation of CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells into T follicular helper cells (T\n                    <jats:sub>FH<\/jats:sub>\n                    ), which guide rare B cells to mature into long-lived plasma cells that produce durable neutralizing antibodies (nAbs). In this issue of the\n                    <jats:italic>JCI<\/jats:italic>\n                    , Parham Ramezani-Rad et al. show that higher doses of saponin QS-21\u2013MPLA nanoparticle (SMNP) adjuvant, combined with BG505 MD39 envelope (Env) protein, enhanced cytokine responses, drove stronger Env-specific T\n                    <jats:sub>FH<\/jats:sub>\n                    responses in blood, and increased Env-specific bone marrow plasma cells compared with lower doses. While tier 2 nAbs were sustained at memory in only a subset of animals, predominantly at the highest adjuvant dose, these findings highlight transient reactogenicity as an essential mechanism \u2014 not a flaw \u2014 for building durable immune memory.\n                  <\/jats:p>","DOI":"10.1172\/jci190524","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T14:01:02Z","timestamp":1744639262000},"source":"Crossref","is-referenced-by-count":1,"title":["Transient pain and long-term gain: adjuvant dose directs immune memory"],"prefix":"10.1172","volume":"135","author":[{"given":"Pabitra B.","family":"Pal","sequence":"first","affiliation":[{"name":"Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smita S.","family":"Iyer","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, University of 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