{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:59:29Z","timestamp":1787018369970,"version":"build-2736575974"},"reference-count":29,"publisher":"American Society for Clinical Investigation","issue":"7","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,1]]},"abstract":"<jats:p>\n                    Immune correlates of protection against infection with\n                    <jats:italic>Mycobacterium<\/jats:italic>\n                    <jats:italic>tuberculosis<\/jats:italic>\n                    (Mtb) remain elusive. In this issue of the\n                    <jats:italic>JCI<\/jats:italic>\n                    , Dallmann-Sauer and authors demonstrate that lack of tuberculin skin test (TST) and interferon \u03b3 release assay (IGRA) conversion among people with HIV despite years-long Mtb exposure is associated with alveolar lymphocytosis, including specific poly-cytotoxic T cells, and M1-type alveolar macrophages with a stronger ex vivo response to the pathogen. Studies in these rare individuals, termed \u201cTB resisters\u201d and in tuberculosis household contacts who are repeatedly IGRA negative in the months after a specific exposure event (known as \u201cearly clearers\u201d) help elucidate manipulatable mechanisms to boost protection against Mtb infection.\n                  <\/jats:p>","DOI":"10.1172\/jci191423","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T14:01:19Z","timestamp":1743429679000},"source":"Crossref","is-referenced-by-count":6,"title":["Insights into protection against Mycobacterium tuberculosis infection: time to officially confirm another phenotype?"],"prefix":"10.1172","volume":"135","author":[{"given":"Todia P.","family":"Setiabudiawan","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Radboud Community for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands."},{"name":"Research Center for Care and Control of Infectious Diseases, Universitas Padjadjaran, Jawa Barat, Indonesia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7006-0549","authenticated-orcid":true,"given":"Philip C.","family":"Hill","sequence":"additional","affiliation":[{"name":"Centre for International Health, University of Otago, Dunedin, New Zealand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"DiNardo","sequence":"additional","affiliation":[{"name":"The Global Tuberculosis Program, Texas Children\u2019s Hospital, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6233-6410","authenticated-orcid":true,"given":"Reinout","family":"van Crevel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Radboud Community for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands."},{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2025,4,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(24)00028-6"},{"key":"B2","unstructured":"World Health Organization. Global tuberculosis report 2024. https:\/\/www.who.int\/teams\/global-tuberculosis-programme\/tb-reports\/global-tuberculosis-report-2024 Updated October 29, 2024. Accessed February 26, 2025"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(19)30309-3"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1817-8"},{"issue":"8","key":"B5","first-page":"1351","article-title":"Early clearance of mycobacterium tuberculosis: the INFECT Case Contact Cohort Study in Indonesia","volume":"221","author":"Verrall","year":"2020","journal-title":"J Infect Dis"},{"key":"B6","doi-asserted-by":"crossref","unstructured":"Schwalb A, et al. 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