{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:59:11Z","timestamp":1789610351080,"version":"build-2803163510"},"reference-count":19,"publisher":"American Society for Clinical Investigation","issue":"8","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,15]]},"abstract":"<jats:p>\n                    Castration-resistant prostate cancer frequently metastasizes to the liver, and prostate cancer liver metastases often present a neuroendocrine phenotype (i.e., neuroendocrine prostate cancer [NEPC]), but the underlying molecular underpinnings remain unclear. In this issue of the\n                    <jats:italic>JCI<\/jats:italic>\n                    , Liu et al. demonstrate that the neurotransmitter serotonin (also known as 5-hydroxytryptamine), produced by NEPC cells, gained access to and activated neutrophils by modifying histone 3 (H3) to form neutrophil extracellular traps, which in turn promoted NEPC macrometastases in the liver. The study suggests that blocking serotonin transport to neutrophils and inhibiting the enzymes that catalyze serotonin-mediated H3 modifications may represent alternative approaches to treating prostate cancer liver metastases.\n                  <\/jats:p>","DOI":"10.1172\/jci191687","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T14:01:02Z","timestamp":1744639262000},"source":"Crossref","is-referenced-by-count":9,"title":["Serotonin sets up neutrophil extracellular traps to promote neuroendocrine prostate cancer metastasis in the liver"],"prefix":"10.1172","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5029-1174","authenticated-orcid":true,"given":"Dean G.","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA."},{"name":"Experimental Therapeutics Graduate Program, University at Buffalo and Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2021.11.001"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.217068"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.09.003"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1172\/JCI128212"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32701-6"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.47248\/chp2401010005"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1172\/JCI183544"},{"issue":"7","key":"B8","article-title":"5-HT orchestrates histone serotonylation and citrullination to drive neutrophil extracellular traps and liver metastasis","volume":"54","author":"Liu","year":"2021","journal-title":"Cell Prolif"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03075-7"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2024.01.013"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.03.008"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2024.12.004"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-24-0291"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2022590118"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22031268"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1085569"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1126\/science.1236361"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah5072"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-18-0605"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/191687\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T19:18:34Z","timestamp":1779218314000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/191687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,15]]},"references-count":19,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,2,27]]},"published-print":{"date-parts":[[2025,4,15]]}},"alternative-id":["10.1172\/JCI191687"],"URL":"https:\/\/doi.org\/10.1172\/jci191687","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,15]]},"article-number":"e191687"}}