{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T19:09:30Z","timestamp":1783883370898,"version":"3.55.0"},"reference-count":26,"publisher":"American Society for Clinical Investigation","issue":"12","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,16]]},"abstract":"<jats:p>\n                    Bardet-Biedl syndrome (BBS) is a complex genetic condition that can affect multiple organ systems, frequently causing pigmentary retinopathy, renal abnormalities, polydactyly, and obesity. Metabolic disturbances including obesity, unsuppressed appetite, and an increased risk of type 2 diabetes (T2D) present clinical management challenges. In this issue of the\n                    <jats:italic>JCI<\/jats:italic>\n                    , Singh et al. present a mouse model of a specific BBS subtype with genetic deletion of the\n                    <jats:italic>Bbs5<\/jats:italic>\n                    gene. The model recapitulates many of the clinical features observed in patients living with BBS5 and sheds light on adipocyte biology, as well as the hypothalamic mechanisms driving hunger- and food-seeking behaviors that fuel the adverse metabolic phenotype. Importantly, exogenous GLP-1 receptor agonist treatment suppressed both appetite and weight, opening opportunities for direct translation into the clinical setting.\n                  <\/jats:p>","DOI":"10.1172\/jci191822","type":"journal-article","created":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T14:00:37Z","timestamp":1749996037000},"source":"Crossref","is-referenced-by-count":3,"title":["Should GLP-1 receptor agonist therapy be used to treat obesity in Bardet-Biedl syndrome?"],"prefix":"10.1172","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3170-8533","authenticated-orcid":true,"given":"Jeremy W.","family":"Tomlinson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2025,6,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15480"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI184636"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-012-2220-y"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2290"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-023-01280-x"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1172\/JCI32357"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1210192110"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp031"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-01459"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1080\/13816810.2020.1810282"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1111\/nep.14087"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24108729"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/srep34764"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(22)00277-7"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-022-02602-4"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(24)00273-0"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.galenos.2023.2023-7-7"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1111\/ijpo.12703"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30406"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03320410"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047-6310.2013.00182.x"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-023-02723-4"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2032183"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1607141"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1111\/cob.12546"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15398"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/191822\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T17:56:30Z","timestamp":1779213390000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/191822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,16]]},"references-count":26,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,4,15]]},"published-print":{"date-parts":[[2025,6,16]]}},"alternative-id":["10.1172\/JCI191822"],"URL":"https:\/\/doi.org\/10.1172\/jci191822","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,16]]},"article-number":"e191822"}}