{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T03:09:20Z","timestamp":1789528160114,"version":"build-2803163510"},"reference-count":19,"publisher":"American Society for Clinical Investigation","issue":"9","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,1]]},"abstract":"<jats:p>\n                    There are known sex (i.e., biological) and gender (i.e., social) differences in the epidemiology and outcomes of chronic kidney disease. In this issue of the\n                    <jats:italic>JCI<\/jats:italic>\n                    , van Eeghen et al. provide a prospective multicenter observational study of transgender individuals initiating masculinizing and feminizing hormone therapy. Testosterone and estrogen with testosterone blockade had differential effects on kidney physiology including renal plasma blood flow, measured glomerular filtration rate, tubular biomarkers, and various proteins involved in inflammatory and repair pathways. The findings suggest that estrogen is renoprotective and that testosterone may be harmful to kidney function, but requires validation in larger, more diverse cohorts. The insights gained also need to be examined in the context of both endogenous and exogenous sex hormones in individuals over the life cycle.\n                  <\/jats:p>","DOI":"10.1172\/jci191907","type":"journal-article","created":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T07:59:44Z","timestamp":1746086384000},"source":"Crossref","is-referenced-by-count":6,"title":["The differential effects of sex hormone therapy on kidney function: insights into biological sex differences"],"prefix":"10.1172","volume":"135","author":[{"given":"David","family":"Collister","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Nephrology, University of Alberta, Edmonton, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeera","family":"Levin","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nephrology, University of British Columbia and St. Paul\u2019s Hospital, Vancouver, British Columbia, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2025,5,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2023.10.018"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2024.08.038"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-023-00784-z"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfw084"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-020-01594-x"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v11.i3.66"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01890222"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.0000000000000289"},{"issue":"9","key":"B9","doi-asserted-by":"crossref","DOI":"10.1172\/JCI190850","article-title":"Unveiling mechanisms underlying kidney function changes during sex hormone therapy","volume":"135","author":"van Eeghen","year":"2025","journal-title":"J Clin Invest"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2024.06.029"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft466"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1657-6"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-023-00787-w"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2024.06.030"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000002632"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.7326\/M17-0577"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2019.06.009"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200241050-00002"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.07420619"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/191907\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T19:17:23Z","timestamp":1779218243000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/191907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,1]]},"references-count":19,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,3,25]]},"published-print":{"date-parts":[[2025,5,1]]}},"alternative-id":["10.1172\/JCI191907"],"URL":"https:\/\/doi.org\/10.1172\/jci191907","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,1]]},"article-number":"e191907"}}