{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T07:20:26Z","timestamp":1780730426367,"version":"3.54.1"},"reference-count":18,"publisher":"American Society for Clinical Investigation","issue":"10","license":[{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,15]]},"abstract":"<jats:p>\n                    IgA nephropathy (IgAN) is a highly prevalent type of primary glomerulonephritis. IgAN involves mesangial deposition of immune complexes leading to complement activation, inflammation, and glomerular injury. A key hit for pathogenesis involves aberrant O-glycosylation in the hinge region of IgA. Despite its prevalence, however, the mechanisms underlying IgAN remain incompletely understood. In this issue of the\n                    <jats:italic>JCI<\/jats:italic>\n                    , Prakash and colleagues used whole-exome sequencing of two IgAN probands to identify loss-of-function variants in\n                    <jats:italic>GALNT14<\/jats:italic>\n                    leading to loss of the enzyme GalNAc-T14, which is involved in O-glycosylation. The authors then performed a classical bedside-to-bench investigation using a\n                    <jats:italic>\n                      Galnt14\n                      <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    <\/jats:italic>\n                    mouse model and connected loss of GalNAc-T14 to excess IgA production, impaired B lymphocyte homing, and defective intestinal mucus production. These findings build a more unified understanding of IgAN pathogenesis from defective O-glycosylation with loss-of-function variants in\n                    <jats:italic>GALNT14<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1172\/jci192687","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T14:00:41Z","timestamp":1747231241000},"source":"Crossref","is-referenced-by-count":4,"title":["GALNT14 deficiency: connecting multiple links in the IgA nephropathy pathogenetic chain"],"prefix":"10.1172","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9641-2445","authenticated-orcid":true,"given":"John","family":"Pell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9567-4299","authenticated-orcid":true,"given":"Madhav C.","family":"Menon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2025,5,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1436923"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fneph.2025.1545329"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.0000000000000135"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020109"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2012.58"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2007.10.010"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2004.01.002"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2011.05.033"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1159\/000348461"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1999.00823.x"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-023-01422-x"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1172\/JCI181164"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2023.02.1072"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1990.204"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2018.05.020"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1080\/10409239891204198"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2018.05.014"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1159\/000486018"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/192687\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T22:54:24Z","timestamp":1779231264000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/192687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,15]]},"references-count":18,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,5,15]]},"published-print":{"date-parts":[[2025,5,15]]}},"alternative-id":["10.1172\/JCI192687"],"URL":"https:\/\/doi.org\/10.1172\/jci192687","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,15]]},"article-number":"e192687"}}