{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:50:49Z","timestamp":1792651849852,"version":"4.5.0"},"reference-count":46,"publisher":"American Society for Clinical Investigation","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Invest."],"published-print":{"date-parts":[[2003,11,15]]},"DOI":"10.1172\/jci200319270","type":"journal-article","created":{"date-parts":[[2003,11,14]],"date-time":"2003-11-14T15:59:23Z","timestamp":1068825563000},"page":"1486-1494","source":"Crossref","is-referenced-by-count":761,"title":["Targeted disruption of TGF-\u03b21\/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction"],"prefix":"10.1172","volume":"112","author":[{"given":"Misako","family":"Sato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuteru","family":"Muragaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizuya","family":"Saika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita B.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Ooshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1681\/ASN.V7122495","volume":"7","author":"Eddy","year":"1996","journal-title":"J. Am. Soc. Nephrol."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199811123392007"},{"key":"B3","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/S0002-9440(10)62503-5","volume":"159","author":"Stahl","year":"2001","journal-title":"Am. J. Pathol."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005043421807"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1997.190"},{"key":"B6","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/S0002-9440(10)62533-3","volume":"159","author":"Yang","year":"2001","journal-title":"Am. J. Pathol."},{"key":"B7","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1016\/S0002-9440(10)61150-9","volume":"160","author":"Zeisberg","year":"2002","journal-title":"Am. J. Pathol."},{"key":"B8","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1172\/JCI0215518","volume":"100","author":"Iwano","year":"2002","journal-title":"J. Clin. Invest."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000014252.37680.E4"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.8.1745"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.10066"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81696-7"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.5.1280"},{"key":"B14","doi-asserted-by":"crossref","first-page":"F861","DOI":"10.1152\/ajprenal.00362.2001","volume":"283","author":"Klahr","year":"2002","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"B15","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1182\/blood.V90.5.1768","volume":"90","author":"Feldman","year":"1997","journal-title":"Blood."},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00571-2"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(67)90160-1"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/nrm757"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/35000025"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67097-8"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000031827.16102.C1"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M208258200"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf366"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M005912200"},{"key":"B25","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1091\/mbc.12.1.27","volume":"12","author":"Bhowmick","year":"2001","journal-title":"Mol. Biol. Cell."},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M106176200"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5410.2080"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.1154"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M102382200"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.01641.x"},{"key":"B31","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/S0002-9440(10)64926-7","volume":"160","author":"Flanders","year":"2002","journal-title":"Am. J. Pathol."},{"key":"B32","doi-asserted-by":"crossref","first-page":"L585","DOI":"10.1152\/ajplung.00151.2001","volume":"282","author":"Zhao","year":"2002","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"B33","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000147748","volume":"154","author":"Hay","year":"1995","journal-title":"Acta Anat. (Basel)."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.23.8184-8188.2001"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/12971"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041430222"},{"key":"B37","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1161\/01.RES.83.10.1027","volume":"16","author":"Papadaki","year":"1998","journal-title":"Circ. Res."},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.110.4.1361"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.111.2.757"},{"key":"B40","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/S0092-8674(00)81460-9","volume":"26","author":"Crawford","year":"1998","journal-title":"Cell."},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80545-0"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/nature01413"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.16.5788"},{"key":"B44","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S0006-291X(88)80319-X","volume":"15","author":"Wiseman","year":"1988","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B45","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1016\/S0002-9440(10)64802-X","volume":"157","author":"Cosgrove","year":"2000","journal-title":"Am. J. Pathol."},{"key":"B46","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1097\/00041552-199707000-00014","volume":"6","author":"Peters","year":"1997","journal-title":"Curr. Opin. Nephrol. Hypertens."}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jci.org\/articles\/view\/19270\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T12:53:45Z","timestamp":1691067225000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jci.org\/articles\/view\/19270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,11,15]]},"references-count":46,"aliases":["10.1172\/jci19270","10.1172\/jci19270"],"journal-issue":{"issue":"10","published-print":{"date-parts":[[2003,11,15]]}},"URL":"https:\/\/doi.org\/10.1172\/jci200319270","relation":{},"ISSN":["0021-9738"],"issn-type":[{"value":"0021-9738","type":"print"}],"subject":[],"published":{"date-parts":[[2003,11,15]]}}}