{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T03:58:37Z","timestamp":1781841517742,"version":"3.54.5"},"reference-count":72,"publisher":"American Society for Clinical Investigation","issue":"23","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Intramural Research Program of the NIH, National Institute of Environmental Health Sciences","award":["Z1AES103311-01"],"award-info":[{"award-number":["Z1AES103311-01"]}]},{"name":"Postdoctoral Research Associate (PRAT) fellowship from the National Institute of General Medical Sciences","award":["FI2GM154603"],"award-info":[{"award-number":["FI2GM154603"]}]},{"DOI":"10.13039\/100009633","name":"NIH\/NICHD","doi-asserted-by":"crossref","award":["R01 HD-042311"],"award-info":[{"award-number":["R01 HD-042311"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NICHD","award":["R01HD104813"],"award-info":[{"award-number":["R01HD104813"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:p>\n                    Estrogen is a critical regulator of endometrial health. Aberrant estrogen stimulation can result in infertility, endometrial cancer, and endometriosis. Here, we identified\n                    <jats:italic>Zinc Finger MIZ-Type Containing 1<\/jats:italic>\n                    (\n                    <jats:italic>Zmiz1<\/jats:italic>\n                    ) as a coregulator of uterine estrogen signaling.\n                    <jats:italic>ZMIZ1<\/jats:italic>\n                    is colocalized with an estrogen receptor \u03b1\u2013binding (ESR1-binding) super enhancer.\n                    <jats:italic>ZMIZ1<\/jats:italic>\n                    mutations are found in endometrial cancer and its RNA levels trend toward reduction in endometrium of patients with endometriosis.\n                    <jats:italic>ZMIZ1<\/jats:italic>\n                    is dynamically expressed in human endometrial tissues during the menstrual cycle. Disrupting\n                    <jats:italic>ZMIZ1<\/jats:italic>\n                    in cultured human endometrial stromal cells resulted in impaired cell proliferation and decidual differentiation. Ablation of\n                    <jats:italic>Zmiz1<\/jats:italic>\n                    using the Pgr\n                    <jats:sup>Cre<\/jats:sup>\n                    mouse (Zmiz1\n                    <jats:sup>d\/d<\/jats:sup>\n                    ) resulted in infertility and accelerated age-dependent uterine fibrosis. Zmiz1\n                    <jats:sup>d\/d<\/jats:sup>\n                    mice showed reduced ovulation and progesterone levels while maintaining normal serum prolactin during pregnancy. Uteri of Zmiz1\n                    <jats:sup>d\/d<\/jats:sup>\n                    mice were unable to undergo a hormonally induced decidual response, had decreased expression of stromal progesterone receptor (PGR) and decreased stromal and epithelial cell proliferation. Analysis of the transcriptome of Zmiz1\n                    <jats:sup>d\/d<\/jats:sup>\n                    mouse uteri showed decreased E2F, CCNA2, and FOXM1 signaling. Challenging ovariectomized Zmiz1\n                    <jats:sup>d\/d<\/jats:sup>\n                    mice with estrogen resulted in a decreased amplitude of some estrogen-regulated gene responses. Our findings demonstrate the importance of ZMIZ1 as an ESR1 coregulator in uterine biology and pathology.\n                  <\/jats:p>","DOI":"10.1172\/jci193212","type":"journal-article","created":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T19:00:54Z","timestamp":1764529254000},"source":"Crossref","is-referenced-by-count":5,"title":["Transcriptional coregulator ZMIZ1 modulates estrogen responses that are essential for healthy endometrial function"],"prefix":"10.1172","volume":"135","author":[{"given":"Sylvia C.","family":"Hewitt","sequence":"first","affiliation":[{"name":"Pregnancy & Female Reproduction Group, Reproductive and Developmental Biology Lab, NIEHS, Research Triangle Park, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Orellana","sequence":"additional","affiliation":[{"name":"Pregnancy & Female Reproduction Group, Reproductive and Developmental Biology Lab, NIEHS, Research Triangle Park, North Carolina, 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