{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:33:48Z","timestamp":1792787628123,"version":"4.5.0"},"reference-count":0,"publisher":"American Society for Clinical Investigation","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Diabetes and Digestive and Kidney Diseases","award":["R01DK141495"],"award-info":[{"award-number":["R01DK141495"]}],"id":[{"id":"https:\/\/ror.org\/00adh9b73","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Institute of Diabetes and Digestive and Kidney Diseases","award":["F31DK142280"],"award-info":[{"award-number":["F31DK142280"]}],"id":[{"id":"https:\/\/ror.org\/00adh9b73","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Institute of Diabetes and Digestive and Kidney Diseases","award":["DK124238"],"award-info":[{"award-number":["DK124238"]}],"id":[{"id":"https:\/\/ror.org\/00adh9b73","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Novo Nordisk Fonden","award":["NNF18OC0033444"],"award-info":[{"award-number":["NNF18OC0033444"]}],"id":[{"id":"https:\/\/ror.org\/04txyc737","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Novo Nordisk Fonden","award":["NNF16OC0021496"],"award-info":[{"award-number":["NNF16OC0021496"]}],"id":[{"id":"https:\/\/ror.org\/04txyc737","id-type":"ROR","asserted-by":"crossref"}]},{"name":"novo nordisk fonden","award":["NNF18CC0034900"],"award-info":[{"award-number":["NNF18CC0034900"]}],"id":[{"id":"https:\/\/ror.org\/04txyc737","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Lundbeckfonden","award":["R190-2014-3904"],"award-info":[{"award-number":["R190-2014-3904"]}],"id":[{"id":"https:\/\/ror.org\/03hz8wd80","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Key Program of NSFC-Tongyong Union Foundation","award":["32371212"],"award-info":[{"award-number":["32371212"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    GLP-1 receptor agonists (GLP1RAs) effectively reduce feeding to treat obesity, although nausea and other aversive side effects of these drugs can limit their use. Brainstem circuits that promote satiation and mediate the physiological control of body weight can be distinguished from those that cause aversion. It remains unclear whether brainstem\n                    <jats:italic>Glp1r<\/jats:italic>\n                    neurons contribute to the normal regulation of energy balance and whether GLP1RAs control appetite via circuits distinct from those that mediate aversive responses, however. Here, we silenced\n                    <jats:italic>Glp1r<\/jats:italic>\n                    neurons in the nucleus of the solitary tract or area postrema (NTS\n                    <jats:sup>Glp1r<\/jats:sup>\n                    or AP\n                    <jats:sup>Glp1r<\/jats:sup>\n                    neurons, respectively) or restored their GLP1R signaling on an otherwise GLP1R-deficient background to determine physiological and pharmacological roles for each neuron population. Although NTS\n                    <jats:sup>Glp1r<\/jats:sup>\n                    neurons contributed to the normal restraint of food intake and body weight, they failed to mediate GLP1RA-dependent weight loss. In contrast, while we detected no role for AP\n                    <jats:sup>Glp1r<\/jats:sup>\n                    neurons in physiological feeding, they mediated both the weight-lowering and aversive effects of GLP1RAs. Therefore, while non-aversive NTS\n                    <jats:sup>Glp1r<\/jats:sup>\n                    neurons control physiologic satiation they do not contribute to weight loss during GLP1RA treatment. Rather, AP\n                    <jats:sup>Glp1r<\/jats:sup>\n                    neurons mediate both the weight-lowering and aversive effects of GLP1RAs, preventing the separation of their nauseating and weight-loss effects at a circuit level.\n                  <\/jats:p>","DOI":"10.1172\/jci193743","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T16:01:21Z","timestamp":1789488081000},"source":"Crossref","is-referenced-by-count":1,"title":["A single dorsal vagal complex circuit mediates the aversive and anorectic responses to GLP1R agonists"],"prefix":"10.1172","author":[{"given":"Warren T.","family":"Yacawych","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoxiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Zhejiang University-University of Edinburgh Institute, International Campus, Zhejiang University, Haining, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shad","family":"Hassan","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cagri","family":"Bodur","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Walters","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Santinga","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederike","family":"Sass","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"deVaux","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stace","family":"Kernodle","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Michigan, Ann Arbor, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5072-4491","authenticated-orcid":true,"given":"Jenny M.","family":"Brown","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan M.","family":"Belmont-Rausch","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5363-4494","authenticated-orcid":true,"given":"Alan C.","family":"Rupp","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4192-9639","authenticated-orcid":true,"given":"Abigail J.","family":"Tomlinson","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zitian","family":"Lin","sequence":"additional","affiliation":[{"name":"Zhejiang University-University of Edinburgh Institute, International Campus, Zhejiang University, Haining, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"VanTongeren","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Secher","sequence":"additional","affiliation":[{"name":"Global Drug Discovery, Novo Nordisk A\/S, Mal\u00f8v, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Raun","sequence":"additional","affiliation":[{"name":"Research and Early Development, Novo Nordisk A\/S, Mal\u00f8v, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0207-4831","authenticated-orcid":true,"given":"Tune H.","family":"Pers","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randy J.","family":"Seeley","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Michigan, Ann Arbor, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9468-2046","authenticated-orcid":true,"given":"Martin G.","family":"Myers Jr.","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Qiu","sequence":"additional","affiliation":[{"name":"Zhejiang University-University of Edinburgh Institute, International Campus, Zhejiang University, Haining, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2026,9,15]]},"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jci.org\/articles\/view\/193743\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T16:01:23Z","timestamp":1789488083000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jci.org\/articles\/view\/193743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,15]]},"references-count":0,"alternative-id":["10.1172\/JCI193743"],"URL":"https:\/\/doi.org\/10.1172\/jci193743","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,15]]}}}