{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T18:12:28Z","timestamp":1779214348710,"version":"3.51.4"},"reference-count":23,"publisher":"American Society for Clinical Investigation","issue":"12","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,16]]},"abstract":"<jats:p>\n                    The effect of food intake patterns on growth remain largely unknown. In this issue of the\n                    <jats:italic>JCI<\/jats:italic>\n                    , Hornsby et al. provide compelling evidence that, in young males, confining food intake to three meals a day entrains preprandial ghrelin release, leading to postprandial growth hormone pulse release that is associated with an increase in epiphysial plate expansion \u2014 a measure indicative of increased bone growth. The positive effects of discrete meal intake, on bone, was dependent on an intact ghrelin signaling system. This Commentary posits that meal-entrained ghrelin release may enhance skeletal accrual, whether through direct action on bone cells, via stimulation of growth hormone secretion, or in concert with other nutrient-responsive hormones. Coordinating these hormonal cues with food intake could maximize bone acquisition and improve bone health throughout the lifespan.\n                  <\/jats:p>","DOI":"10.1172\/jci194079","type":"journal-article","created":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T14:00:37Z","timestamp":1749996037000},"source":"Crossref","is-referenced-by-count":0,"title":["Regular meals matter: bone growth and beyond"],"prefix":"10.1172","volume":"135","author":[{"given":"Rhonda D.","family":"Kineman","sequence":"first","affiliation":[{"name":"Section of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA."},{"name":"Research and Development Division, Jesse Brown VA Medical Center, Chicago, Illinois, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoshana","family":"Yakar","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathobiology, David B. 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